93702-69-3Relevant academic research and scientific papers
ELECTROPHILIC AND NUCLEOPFILIC SUBSTITUTION REACTION IN THE SERIES OF 3-METHYLXANTHINE AND ITS DERIVATIVES
Priimenko, B.A.,Romanenko, N.I.,Klyuev, N.A.,Fedulova, I.V.,Gnatov, N.I.,Garmash, S.N.
, p. 924 - 927 (2007/10/02)
The reactions of nitration and bromination of 3-methylxanthine were studied.Heating 3-methyl-8-nitroxanthine with con.HCl and HBr leads to a replacement of the nitro group by a halogen atom.The alkylation of 8-haloxanthines by alkyl halides were studied.It was shown that boiling 7-substituted 3-methyl-8-bromoxanthine derivatilves with POCl3 and PCl5 leads to the formation of 2,6,8-trichloro-7-alkylpurines.The structure of synthetized compounds was confirmed by counter synthesis, the data of elementary analysis, and mass spectrometry.
