93703-28-7Relevant academic research and scientific papers
Xanthine derivatives as DPP-IV inhibitors
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, (2008/06/13)
The present invention provides novel compounds exhibiting an excellent DPPIV inhibition effect. The compounds are represented by the formula: wherein, m is 0 or 1; n is 0; R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, and R42 each represent a hydrogen atom; X represents an alkynyl group, an aryl group, and such, which group may be substituted; and, R1 and R2 each independently represents a hydrogen atom, an alkyl group, an alkoxyl group, or such, or salts or hydrates thereof.
Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
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, (2008/06/13)
The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
ELECTROPHILIC AND NUCLEOPFILIC SUBSTITUTION REACTION IN THE SERIES OF 3-METHYLXANTHINE AND ITS DERIVATIVES
Priimenko, B.A.,Romanenko, N.I.,Klyuev, N.A.,Fedulova, I.V.,Gnatov, N.I.,Garmash, S.N.
, p. 924 - 927 (2007/10/02)
The reactions of nitration and bromination of 3-methylxanthine were studied.Heating 3-methyl-8-nitroxanthine with con.HCl and HBr leads to a replacement of the nitro group by a halogen atom.The alkylation of 8-haloxanthines by alkyl halides were studied.It was shown that boiling 7-substituted 3-methyl-8-bromoxanthine derivatilves with POCl3 and PCl5 leads to the formation of 2,6,8-trichloro-7-alkylpurines.The structure of synthetized compounds was confirmed by counter synthesis, the data of elementary analysis, and mass spectrometry.
