93710-27-1

Basic information

• Product Name: leuconolam
• Synonyms: leuconolam;Leucolam;(8aR,12aS,14bS)-8a-Ethyl-7,8,8a,10,11,12a-hexahydro-12a-hydroxyindolizino[8,1-ef][1]benzazonine-6,13(5H,9H)-dione
• CAS NO: 93710-27-1
• Molecular Formula: C19H22N2O3
• Molecular Weight: 326.4
• Mol File: 93710-27-1.mol

Chemical Properties

• Boiling Point: 615.6°Cat760mmHg
• Flash Point: 326.1°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 5.17E-16mmHg at 25°C
• Refractive Index: 1.652
• CAS DataBase Reference: leuconolam(CAS DataBase Reference)
• NIST Chemistry Reference: leuconolam(93710-27-1)
• EPA Substance Registry System: leuconolam(93710-27-1)

Safety Data

• Hazardous Substances Data: 93710-27-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Leuconolam is used as a potential medicinal compound for its anti-inflammatory and analgesic effects, making it a candidate for the development of drugs to treat pain and inflammation.
Used in Antimicrobial Applications:
Leuconolam is used as an antimicrobial agent due to its ability to combat microbial infections, which could lead to the creation of new antibiotics or antifungal medications.
Used in Antidiabetic Applications:
Leuconolam is used as an antidiabetic agent for its potential to manage blood sugar levels, indicating its possible use in the development of treatments for diabetes.
Used in Research and Development:
Leuconolam is used as a subject of ongoing research to further understand its mechanisms of action and explore its potential therapeutic applications in various medical conditions, pending further studies to confirm its safety and efficacy.

InChI:InChI=1/C19H22N2O3/c1-2-18-9-5-11-21-17(23)12-14(19(18,21)24)13-6-3-4-7-15(13)20-16(22)8-10-18/h3-4,6-7,12,24H,2,5,8-11H2,1H3,(H,20,22)

Upstream product

• 128529-80-6 6β,7β-dibromodiazaspiroleuconolam 
• 1236143-34-2 (-)-scholarisine G 

Downstream Products

• 1538555-29-1 (+)-11-(2-aminophenyl)-4a-ethyl-3,4,4a,5,6,7-hexahydropyrano[3,2-h]indolizine-2,9-dione 
• 109305-79-5 leuconolam methyl ether 

Relevant articles and documents

Total Syntheses of (-)-Mersicarpine, (-)-Scholarisine G, (+)-Melodinine E, (-)-Leuconoxine, (-)-Leuconolam, (-)-Leuconodine A, (+)-Leuconodine F, and (-)-Leuconodine C: Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G and Leu

(Chemical Equation Presented) Enantioselective total syntheses of title natural products from a common cyclohexenone derivative (S)-18 were reported. Ozonolysis of (S)-18 afforded a stable diketo ester (R)-17 that was subsequently converted to two skeleta

Transformations of the 2,7- Seco Aspidosperma alkaloid leuconolam, structure revision of epi -leuconolam, and partial syntheses of leuconoxine and leuconodines A and F

Several transformations of the seco Aspidosperma alkaloid leuconolam were carried out. The based-induced reaction resulted in cyclization to yield two epimers, the major product corresponding to the optical antipode of a (+)-meloscine derivative. The structures and relative configuration of the products were confirmed by X-ray diffraction analysis. Reaction of leuconolam and epi-leuconolam with various acids, molecular bromine, and hydrogen gave results that indicated that the structure of the alkaloid, previously assigned as epi-leuconolam, was incorrect. This was confirmed by an X-ray diffraction analysis, which revealed that epi-leuconolam is in fact 6,7-dehydroleuconoxine. Short partial syntheses of the diazaspiro indole alkaloid leuconoxine and the new leuconoxine-type alkaloids leuconodines A and F were carried out.