937275-23-5

Basic information

• Product Name: Montelukast Methyl Ketone
• Synonyms: 1-[[[(1R)-3-(2-Acetylphenyl)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]p;Montelukast EP IMpurity F;Mok-3 Keto;Montelukast Methyl Ketone;[1-[[[(1R)-3-(2-acetylphenyl)-1-[3-[(E)-2-(7-chloroquinolin-2- yl)ethenyl]phenyl] propyl]sulfanyl]methyl]cyclopropyl]acetic acid;Montelukast Sodium EP impurity F
• CAS NO: 937275-23-5
• Molecular Formula: C₃₄H₃₂ClNO₃S
• Molecular Weight: 570.14078
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 937275-23-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Amber Vial, -20?C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: Montelukast Methyl Ketone(CAS DataBase Reference)
• NIST Chemistry Reference: Montelukast Methyl Ketone(937275-23-5)
• EPA Substance Registry System: Montelukast Methyl Ketone(937275-23-5)

Safety Data

• Hazardous Substances Data: 937275-23-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 937275-23-5 differently. You can refer to the following data:
1. Montelukast Methyl Ketone (Montelukast EP Impurity F; Montelukast USP Related Compound E; Montelukast Methylketone) is a Montelukast (M568000) impurity. A leukotriene antagonist useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agent.
2. Montelukast Methyl Ketone has been a leukotriene antagonist useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agent.

Upstream product

• 162515-68-6 1-(sulfanylmethyl)cyclopropaneacetic acid 
• 184764-13-4 [S-(E)]-1-[2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]-phenyl]-3-hydroxypropyl]phenyl]ethanone 
• 181139-72-0 methyl-[(E)]-2-[3(S)-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl] benzoate 
• 149968-11-6 methyl 2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate 
• 906107-36-6 Methyl [S-(E)]-2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-methanesulfonyloxy-propyl] benzoate 
• 851755-56-1 [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid 
• 676-58-4 methylmagnesium chloride 
• 855473-50-6 1-bromomethylcyclopropyl acetic acid methyl ester 
• 937275-14-4 C₇H₈O₃S*C₂₉H₂₈ClNOS 
• 1013023-54-5 C₆H₁₃N*C₃₄H₃₂ClNO₃S 

Downstream Products

• 1013023-48-7 [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(methylcarbonyl)phenyl] propyl]thio]methyl]cyclopropane acetic acid dicyclohexyl amine salt 
• 1013023-53-4 C₃H₉N*C₃₄H₃₂ClNO₃S 
• 1013023-54-5 C₆H₁₃N*C₃₄H₃₂ClNO₃S 
• 158966-92-8 montelukast 
• 151767-02-1 Montelukast sodium 

Relevant articles and documents

Montelukast sodium intermediate and preparation method and application thereof

The invention relates to a series of novel compounds as shown in a formula (III) and a preparation method thereof. The invention also relates to an application of the novel compounds as shown in the formula (III) in synthesizing Montelukast sodium. The compounds as shown in the formula (III) are critical intermediates in the Montelukast sodium synthesizing process, and play a critical role of synthesizing the final target compound. The intermediate is stable in chemical property, the preparation process is mild in reaction condition, the yield is high, the optical purity is high, and the intermediate is suitable for large-scaled production. The formula is as shown in the description.

PROCESS FOR THE PREPARATION OF MONTELUKAST, AND INTERMEDIATES THEREFOR

The invention relates to processes for making montelukast and to intermediates for use in the process, in particular compounds of formulas 2-7: L=OAc, OTs, OTf5OMs; where X=Cl, Br, I.

QUINOLINE-CONTAINING KETOACIDS AS LEUKOTRIENE ANTAGONISTS

Compounds having the formula I: STR1 are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis and allograft rejection.