937282-79-6Relevant academic research and scientific papers
Development of an enantioselective, kilogram-scale, rhodium-catalysed 1,4-addition
Brock, Sally,Hose, David R.J.,Moseley, Jonathan D.,Parker, Alexandra J.,Patel, Ian,Williams, Andrew J.
, p. 496 - 502 (2013/01/03)
A rhodium-catalysed 1,4-addition of an arylboron species to an α,β-unsaturated ester was the key chirality-inducing step in the synthesis of an API. We describe herein the development of this chemistry, including optimization of reagent charges, reaction
PROCESS FOR PREPARING BETA- (FLUOROPHENYL) -PROPANOATE ESTER DERIVATIVES
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Page/Page column 9-10, (2008/06/13)
A process for preparing a compound of formula (I) comprising reacting a compound of formula (II) with a fluorinated boron species of formula (III) in the presence of: an alcohol; a rhodium (I) pre-catalyst species; a suitable ligand that binds to the rhodium (I) pre-catalyst species to form a catalyst complex; a base; and, a suitable solvent; the process being carried out at a temperature in the range 40 to 110oC. The compounds of formula (I) are useful in the preparation of pharmaceutically active compounds.
