937282-79-6Relevant articles and documents
Development of an enantioselective, kilogram-scale, rhodium-catalysed 1,4-addition
Brock, Sally,Hose, David R.J.,Moseley, Jonathan D.,Parker, Alexandra J.,Patel, Ian,Williams, Andrew J.
, p. 496 - 502 (2013/01/03)
A rhodium-catalysed 1,4-addition of an arylboron species to an α,β-unsaturated ester was the key chirality-inducing step in the synthesis of an API. We describe herein the development of this chemistry, including optimization of reagent charges, reaction