93749-47-4Relevant articles and documents
Copper-Catalyzed Ring Opening of Benzofurans and an Enantioselective Hydroamination Cascade
Xu-Xu, Qing-Feng,Liu, Qiang-Qiang,Zhang, Xiao,You, Shu-Li
supporting information, p. 15204 - 15208 (2018/10/24)
A copper(II) acetate/(R)-DTBM-SEGPHOS-catalyzed ring opening of benzofurans and enantioselective hydroamination cascade with dimethoxymethylsilane (DMMS) and hydroxylamine esters is described. Starting from readily available substituted benzofurans, a series of chiral N,N-dibenzylaminophenols, which are of high interest in pharmaceutical chemistry, were obtained with excellent enantioselectivities (up to 66 % yield, 94 % ee).
An efficient synthesis of Ecopladib
Li, Wei,Li, Jianchang,DeVincentis, Dianne,Mansour, Tarek S.
, p. 7871 - 7876 (2008/12/20)
An efficient synthesis of Ecopladib, an indole inhibitor of cytosolic phospholipase A2α, is described. A new reaction involving indole C3 reductive alkylation using an acetal in the absence of water and a novel transformation of the C2 methyl t
2-Acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof
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Page/Page column 20, (2008/06/13)
The invention relates to 2-acylamino-4-phenylthiazole derivatives of general formula (I): pharmaceutically acceptable acid-addition salts thereof, hydrates or solvates of such derivatives or such pharmaceutically acceptable acid addition salts, intermediates thereto, processes for the preparation thereof, and therapeutic application thereof.