937591-32-7

Usage

Uses

Used in Organic Synthesis:
1-(5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)INDOLIN-1-YL)ETHANONE is used as a key intermediate for the synthesis of various organic compounds. Its unique structure and reactivity allow for the creation of a wide range of molecules with potential applications in different industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)INDOLIN-1-YL)ETHANONE is used as a starting material for the development of new drugs. Its complex structure and potential reactivity make it a valuable compound for designing and synthesizing novel pharmaceutical agents.
Used in Organic and Inorganic Chemistry:
1-(5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)INDOLIN-1-YL)ETHANONE is used as a reagent in the formation of C-B bonds, which are essential in the synthesis of various organic and inorganic compounds. Its boron-containing group provides a unique platform for further chemical modifications and reactions.
Overall, 1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-1-yl)ethanone is a versatile compound with potential applications in various fields, including organic synthesis, pharmaceutical research, and organic and inorganic chemistry. Its unique structure and reactivity make it a promising candidate for further study and development.

Upstream product

• 22190-38-1 5-bromo-N-acetylindoline 
• 73183-34-3 bis(pinacol)diborane 
• 4993-96-8 1-(5-aminoindolin-1-yl)ethanone 

Downstream Products

• 1593884-60-6 1-acetyl-5-(5-phenylpyridin-3-yl)-2,3-dihydro-1H-indole 
• 1622173-21-0 5-(1-acetylindolin-5-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one 

Relevant academic research and scientific papers

Nickel-Catalyzed Borylation of Aryl- and Benzyltrimethylammonium Salts via C-N Bond Cleavage

By developing a mild Ni-catalyzed system, a method for direct borylation of sp2 and sp3 C-N bonds has been established. The key to this hightly efficient C-N bond borylative cleavage depends on the appropriate choice of the nickel catalyst Ni(COD)2, ICy·HCl as a ligand, and the use of 2-ethoxyethanol as the cosolvent. This transformation shows good functional group compatibility and can serve as a powerful synthetic tool for gram-scale synthesis and late-stage C-N borylation of complex compounds.

Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors

Pathologically, high levels of aldosterone are associated with severe cardiovascular diseases such as congestive heart failure, hypertension, and myocardial fibrosis. The inhibition of aldosterone synthase (CYP11B2) to reduce aldosterone levels has been proposed as a promising treatment for diseases related to CYP11B2 because it is the crucial enzyme in the biosynthesis of aldosterone. A series of novel pyridyl- or isoquinolinyl-substituted indolines and indoles was designed via a ligand-based approach. The synthesized compounds were tested and found to be strong CYP11B2 inhibitors. The most potent ones showed IC50 values of less than 3 nM, being similarly potent as fadrozole and LCI699. Among them, compounds 14 and 23 showed good selectivity over the highly homologous CYP11B1, with selectivity factors (SF = IC 50 CYP11B1/IC50 CYP11B2) around 170; thus, they are superior to fadrozole and LCI699 (SFs 50 > 50 μM) of a panel of hepatic CYP enzymes including CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 and the crucial steroidogenic enzymes, CYP17 and CYP19. Because of these advantageous profiles, compounds 14 and 23 are considered to be candidates for further in vivo evaluation.

NEW COMPOUNDS

This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.