937648-82-3

Basic information

• Product Name: 3-Methylpicolinamide
• Synonyms: 3-Methylpicolinamide;3-Methyl-2-pyridinecarboxamide;2-Pyridinecarboxamide,3-methyl-
• CAS NO: 937648-82-3
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.15
• Mol File: 937648-82-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 291 ºC
• Flash Point: 130 ºC
• Appearance: /
• Density: 1.157
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-Methylpicolinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methylpicolinamide(937648-82-3)
• EPA Substance Registry System: 3-Methylpicolinamide(937648-82-3)

Safety Data

• Hazardous Substances Data: 937648-82-3(Hazardous Substances Data)

Usage

General Description

3-Methylpicolinamide is a chemical compound with the molecular formula C7H8N2O and a molecular weight of 136.15 g/mol. It is a derivative of picolinamide, with a methyl group attached to the 3-position of the pyridine ring. 3-Methylpicolinamide is used as a building block in organic synthesis and as a ligand in coordination chemistry. It has potential applications in pharmaceutical research and drug development, particularly as a component of metal-based anticancer agents and catalysts for organic reactions. Its unique structure and reactivity make it a valuable tool in the field of chemical biology and medicinal chemistry.

InChI:InChI=1/C7H8N2O/c1-5-3-2-4-9-6(5)7(8)10/h2-4H,1H3,(H2,8,10)

Upstream product

• 108-99-6 3-Methylpyridine 
• 77287-34-4 formamide 
• 20970-75-6 2-cyano-3-methylpyridine 

Downstream Products

• 1603-40-3 3-methylpyridin-2-ylamine 

Relevant articles and documents

Method for preparing aryl primary amide by adopting metal-catalyzed one-pot method

The invention discloses a method for synthesizing aryl primary amide by adopting a metal-catalyzed one-pot method. The method comprises the steps of: taking aryl bromidess as raw materials, allowing the aryl bromidess to react with a cyanide source under the action of a palladium catalyst, substituting bromine on an aromatic ring with cyano to obtain cyano aromatic hydrocarbon, directly adding anaqueous solution of alkali into the reaction solution without aftertreatment, and carrying out hydrolysis reaction to obtain aryl primary amide. Compared with the prior art, the method for preparing aryl primary amide from the aryl bromides has the advantages of the short synthesis route, fewer reaction steps, simple operation, mild conditions, the high conversion rate, low toxicity and industrialproduction potential.

Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide

One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol.

SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to compounds that can modulate the bioactivity of an orexin receptor such as OX1 or OX2, or both; to pharmaceutical compositions and combinations comprising a compound of the invention; to methods of treatment of malconditions in patients wherein modulation of an orexin receptor is medically indicated; and to methods of preparation of compounds of the invention.