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CAS

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937661-59-1

1-(1-benzylpiperidin-4-yl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 937661-59-1 Structure

  • Basic information

    1. Product Name: 1-(1-benzylpiperidin-4-yl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde
    2. Synonyms:
    3. CAS NO:937661-59-1
    4. Molecular Formula:
    5. Molecular Weight: 296.412
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 937661-59-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(1-benzylpiperidin-4-yl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(1-benzylpiperidin-4-yl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde(937661-59-1)
    11. EPA Substance Registry System: 1-(1-benzylpiperidin-4-yl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde(937661-59-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 937661-59-1(Hazardous Substances Data)

937661-59-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 937661-59-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,7,6,6 and 1 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 937661-59:
(8*9)+(7*3)+(6*7)+(5*6)+(4*6)+(3*1)+(2*5)+(1*9)=211
211 % 10 = 1
So 937661-59-1 is a valid CAS Registry Number.

937661-59-1Downstream Products

937661-59-1Relevant articles and documents

Structure-activity relationship studies of pyrrolone antimalarial agents

Murugesan, Dinakaran,Kaiser, Marcel,White, Karen L.,Norval, Suzanne,Riley, Jennifer,Wyatt, Paul G.,Charman, Susan A.,Read, Kevin D.,Yeates, Clive,Gilbert, Ian H.

, p. 1537 - 1544 (2013/09/12)

Previously reported pyrrolones, such as TDR32570, exhibited potential as antimalarial agents; however, while these compounds have potent antimalarial activity, they suffer from poor aqueous solubility and metabolic instability. Here, further structure-activity relationship studies are described that aimed to solve the developability issues associated with this series of compounds. In particular, further modifications to the lead pyrrolone, involving replacement of a phenyl ring with a piperidine and removal of a potentially metabolically labile ester by a scaffold hop, gave rise to derivatives with improved in vitro antimalarial activities against Plasmodium falciparum K1, a chloroquine- and pyrimethamine-resistant parasite strain, with some derivatives exhibiting good selectivity for parasite over mammalian (L6) cells. Three representative compounds were selected for evaluation in a rodent model of malaria infection, and the best compound showed improved ability to decrease parasitaemia and a slight increase in survival.

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