93773-63-8

Upstream product

• 1262325-90-5 5-(1-benzenesulfonylindol-3-yl)-2-butyloxazole 
• 7269-72-9 3-indolylglyoxal 
• 616-06-8 2-amino-hexanoic acid 
• 703-80-0 3-acetylindole 
• 75622-06-9 N-[2-(1H-indol-3-yl)ethyl]pentanamide 
• 110-59-8 pentanonitrile 
• 99532-45-3 3-acetyl-1-benzenesulfonylindole 
• 1236196-99-8 pentanoic acid [2-(1H-indol-3-yl)-2-oxo-ethyl]-amide 

Relevant academic research and scientific papers

First reported propylphosphonic anhydride (T3P) mediated Robinson–Gabriel cyclization. Synthesis of natural and unnatural 5-(3-indolyl)oxazoles

In the present work, a propylphosphonic anhydride (T3P) assisted Robinson–Gabriel cyclization of N-acyl-β-oxotryptamines for the synthesis of 2-substituted-5-(3-indolyl)oxazoles has been developed. The reactions proceeded smoothly in acetonitri

A 5 - (3 - indolyl) - oxazole compound of preparation method

The invention discloses a preparation method of a 5-(3-indolyl)-oxazole compound with a structure as shown in the formula (I). The method comprises the following step: in the presence of iodine and dimethyl sulfoxide, a compound with a structure as shown in the formula (II) and a compound with a structure as shown in the formula (III) undergo a contact reaction. Raw materials used in the preparation method are cheap and easily available. The preparation method is simple and the preparation step is short. In addition, the contact reaction can be carried out by a one kettle way during synthetic operation. Yield is high and can reach 84%. The preparation method provided by the invention is especially suitable for industrial production.

One-pot total synthesis: The first total synthesis of chiral alkaloid pimprinol A and the facile construction of its natural congeners from amino acids

In this work, we accomplished the first total synthesis of chiral alkaloid pimprinol A and the facile construction of its natural congeners: pimprinine, pimprinethine, pimprinaphine, WS-30581A, WS-30581B, laboradorin 1, uguenenazole, balsoxine, texamine in one-pot from commercially available starting materials including amino acids. Further investigating into the mechanism revealed that this improved transformation was achieved by the integration of iodination, Kornblum oxidation, condensation, decarboxylation, annulation, and oxidation reaction sequence.

A novel and short synthesis of naturally occurring 5-(3′-indolyl) oxazoles

A novel, concise, and convenient synthesis of 5-(3′-indolyl)oxazoles using relatively benign reagent [hydroxy(2,4-dinitrobenzenesulfonyloxy)iodo] benezene has been described. The advantages of this procedure include operational simplicity, good yield, and

Synthesis of 5-(3-indolyl)oxazole natural products. Structure revision of Almazole D

The synthesis and utility of β-oxotryptamine and β-oxytryptophan ester synthons provide a convenient entry to 5-(3-indolyl)oxazole natural products leading to a structure revision of almazole D.