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Usage

Uses

Used in Pharmaceutical Industry:
4-Isopropoxy-1H-pyrrolo[2,3-b]pyridine is used as a key intermediate in the synthesis of various pharmaceutical drugs. Its unique chemical structure allows for the development of new drugs with improved efficacy and selectivity. It plays a crucial role in the discovery and optimization of novel therapeutic agents for the treatment of various diseases.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Isopropoxy-1H-pyrrolo[2,3-b]pyridine is employed as a building block for the synthesis of agrochemicals, such as insecticides, herbicides, and fungicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and diseases, thereby improving crop yields and food security.
Used in Organic Chemistry Research:
4-Isopropoxy-1H-pyrrolo[2,3-b]pyridine is used as a versatile building block in organic chemistry research. Its unique pyrrolopyridine ring system provides a platform for the development of new compounds with potential biological activities. Researchers can modify its structure to explore novel chemical reactions and synthesize new compounds with potential applications in various fields, including medicine, materials science, and agriculture.
Used in Materials Science:
4-Isopropoxy-1H-pyrrolo[2,3-b]pyridine has potential applications in materials science due to its unique chemical properties. Its incorporation into various materials can lead to the development of new materials with improved properties, such as enhanced stability, selectivity, and reactivity. This can contribute to the advancement of various technologies, including sensors, catalysts, and energy storage devices.

Upstream product

• 6831-82-9 potassium isopropoxide 
• 55052-28-3 4-chloro-7-azaindole 
• 74420-02-3 1H-pyrrolo<2,3-b>pyridin-4-ol (1,7-Dideazahypoxanthine) 
• 67-63-0 isopropyl alcohol 

Relevant academic research and scientific papers

PYRROLO[2,3-B]PYRIDINE COMPOUNDS, AZAINDOLE COMPOUNDS USED FOR SYNTHESIZING SAID PYRROLO[2,3-B]PYRIDINE COMPOUNDS, METHODS FOR THE PRODUCTION THEREOF, AND USES THEREOF

The invention relates to pyrrolo[2,3-b]pyridine compounds and azaindole compounds used for the synthesis thereof. The invention also relates to methods for the production thereof and the uses thereof. Said novel pyrrolo[2,3-b]pyridine compounds according to the invention have great antiproliferative, apoptotic, and neuroprotective activities. The invention particularly applies to the pharmaceutical field.

Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): Synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/Cyclin A/meriolin complex

We report the synthesis and biological characterization of 3-(pyrimidin-4-yl)-7-azaindoles (meriolins), a chemical hybrid between the natural products meridianins and variolins, derived from marine organisms. Meriolins display potent inhibitory activities toward cyclin-dependent kinases (CDKs) and, to a lesser extent, other kinases (GSK-3, DYRK1A). The crystal structures of 1e (meriolin 5) and variolin B (Bettayeb, K.; Tirado, O. M.; Marionneau-Lambert, S.; Ferandin, Y.; Lozach, O.; Morris, J.; Mateo-Lozano, S.; Drückes, P.; Sch?chtele, C.; Kubbutat, M.; Liger, F.; Marquet, B.; Joseph, B.; Echalier, A.; Endicott, J.; Notario, V.; Meijer, L. Cancer Res. 2007, 67, 8325-8334) in complex with CDK2/cyclin A reveal that the two inhibitors are orientated in very different ways inside the ATP-binding pocket of the kinase. A structure-activity relationship provides further insight into the molecular mechanism of action of this family of kinase inhibitors. Meriolins are also potent antiproliferative and proapoptotic agents in cells cultured either as monolayers or in spheroids. Proapoptotic efficacy of meriolins correlates best with their CDK2 and CDK9 inhibitory activity. Meriolins thus constitute a promising class of pharmacological agents to be further evaluated against the numerous human diseases that imply abnormal regulation of CDKs including cancers, neurodegenerative disorders, and polycystic kidney disease.

3-Amino-1-arylpropyl azaindoles and uses thereof

The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.