937802-35-2Relevant academic research and scientific papers
Novel thiol-based TACE inhibitors: Rational design, synthesis, and SAR of thiol-containing aryl sulfonamides
Govinda Rao,Bandarage, Upul K.,Wang, Tiansheng,Come, Jon H.,Perola, Emanuele,Wei, Yunyi,Tian, Shi-Kai,Saunders, Jeffrey O.
, p. 2250 - 2253 (2008/02/02)
A series of potent thiol-containing aryl sulfonamide TACE inhibitors was designed and synthesized. The SAR and MMP selectivity of the series were investigated. In particular, compound 4b has shown excellent in vitro potency against the isolated TACE enzym
