45347-82-8

Basic information

• Product Name: 3-AZETIDINOL
• Synonyms: 3-AZETIDINOL;AZETIDIN-3-OL;3-Hydroxyazetidine;(S)-methyl 2,2-dimethyl-1,3-dioxolane-4-carboxylate;Azetidin-3-ol, 3-Hydroxyazetane;3-AZETIDINOLHCL
• CAS NO: 45347-82-8
• Molecular Formula: C₃H₇NO
• Molecular Weight: 73.09
• Mol File: 45347-82-8.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 170.7 °C at 760 mmHg
• Flash Point: 120.4 °C
• Appearance: /
• Density: 1.142 g/cm³
• Vapor Pressure: 0.464mmHg at 25°C
• Refractive Index: 1.498
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.51±0.20(Predicted)
• CAS DataBase Reference: 3-AZETIDINOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AZETIDINOL(45347-82-8)
• EPA Substance Registry System: 3-AZETIDINOL(45347-82-8)

Safety Data

• Hazardous Substances Data: 45347-82-8(Hazardous Substances Data)

Usage

General Description

3-Azetidinol, also known as 3-Hydroxyazetidine, is a chemical compound with the molecular formula C3H7NO. It is a cyclic secondary amine with a four-membered ring structure containing an oxygen atom and a hydroxyl group. 3-Azetidinol is used in organic synthesis as a chiral building block for the production of pharmaceutical and agrochemical products. It is also utilized as a ligand in asymmetric catalysis due to its ability to efficiently transfer chirality to a target molecule. Additionally, 3-Azetidinol has potential applications in the development of new materials and in the field of medicinal chemistry for the design of bioactive compounds. Overall, this versatile chemical shows promise in various industries and research fields due to its unique molecular structure and beneficial properties.

InChI:InChI=1/C3H7NO/c5-3-1-4-2-3/h3-5H,1-2H2

Upstream product

• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 
• 141699-55-0 tert-butyl 3-hydroxyazetidine-1-carboxylate 
• 616-30-8 3-Amino-1,2-propanediol 
• 111043-42-6 N-benzyl-3-(trimethylsilyloxy)azetidine 

Downstream Products

• 141699-55-0 tert-butyl 3-hydroxyazetidine-1-carboxylate 
• 392231-63-9 4-butoxy-benzenesulfonic acid 1-(4-butoxy-benzenesulfonyl)-azetidin-3-yl ester 
• 919357-22-5 1-(2,3,6-trifluoro-4-nitrophenyl)azetidin-3-ol 
• 919300-10-0 1-(2,6-difluoro-4-nitro-phenyl)azetidin-3-ol 
• 1146157-51-8 1-(4-isopropylbenzyl)azetidin-3-ol 
• 857280-53-6 1-phenylazetidin-3-ol 
• 1380499-22-8 1-biphenyl-4-yl-3-hydroxylcyclobutylamine 

Relevant articles and documents

AZETIDINE CYCLIC UREAS

Provided are azetidine cyclic urea compounds that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

JAK INHIBITOR

The present invention discloses a series of JAK inhibitors, and particularly discloses a compound of formula (I) or a pharmaceutically acceptable salt thereof and the use thereof in preparation of drugs for treating diseases related to JAK.

CATALYST FOR SYNTHESIZING ETHYLENIMINE AS WELL AS PREPARATION METHOD AND APPLICATION THEREOF

The present invention relates to a catalyst for synthesizing ethylenimine as well as a preparation method and application thereof. The related catalyst comprises a carrier and metal ions loaded on the carrier; the carrier is a composite oxide comprising titanium, silicon and phosphorus elements; the metal ions are magnesium ions, iron ions and cesium ions; the molar ratio of the magnesium ions to the iron ions to the cesium ions is (1-10):1:0.1; the mass of all metal ions is 0.5-10 percent of that of the carrier. In the related preparation method, a catalyst precursor is roasted at the temperature of 350-650° C., so that the catalyst is obtained; the catalyst precursor is the mixture of the carrier, soluble salt of magnesium, soluble salt of iron and soluble salt of cesium. The present invention also provides the application of the catalyst to synthesis of the ethylenimine by using amino alcohol as the raw material. Compared with a common catalyst which has the requirement on the temperature of over 400° C., the catalyst of the present invention obviously reduces the reaction temperature. The prepared catalyst can catalyze the intramolecular dehydration reaction of the amino alcohol and has relatively excellent selectivity.