937816-85-8

Basic information

• Product Name: Ethanone,1-(2-amino-5-chloro-4-fluorophenyl)-
• Synonyms: Ethanone,1-(2-amino-5-chloro-4-fluorophenyl)-;1-(2-AMino-5-chloro-4-fluoro-phenyl)-ethanone;2'-AMino-5'-chloro-4'-fluoroacetophenone
• CAS NO: 937816-85-8
• Molecular Formula: C₈H₇ClFNO
• Molecular Weight: 187.6
• Mol File: 937816-85-8.mol

Chemical Properties

• Boiling Point: 324.8°C at 760 mmHg
• Flash Point: 150.3°C
• Appearance: /
• Density: 1.345g/cm³
• Vapor Pressure: 0.000239mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: Ethanone,1-(2-amino-5-chloro-4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone,1-(2-amino-5-chloro-4-fluorophenyl)-(937816-85-8)
• EPA Substance Registry System: Ethanone,1-(2-amino-5-chloro-4-fluorophenyl)-(937816-85-8)

Safety Data

• Hazardous Substances Data: 937816-85-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
Ethanone,1-(2-amino-5-chloro-4-fluorophenyl)is used as a research compound for studying various biological processes and pathways. Its unique structure with a substituted amino group, chlorine, and fluorine atom on a phenyl ring allows for investigation into its interactions with biological systems and potential therapeutic effects.
Used in Organic Synthesis:
Ethanone,1-(2-amino-5-chloro-4-fluorophenyl)is utilized as a precursor in the synthesis of other organic compounds. Its versatile structure enables the development of new molecules with potential applications in various fields, such as pharmaceuticals, agrochemicals, and materials science.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Ethanone,1-(2-amino-5-chloro-4-fluorophenyl)is employed as a building block for the design and synthesis of novel drug candidates. Its unique functional groups and structural features can be exploited to create molecules with improved pharmacological properties, such as enhanced potency, selectivity, and bioavailability.
Used in Drug Discovery:
Ethanone,1-(2-amino-5-chloro-4-fluorophenyl)is used in drug discovery efforts to identify new therapeutic agents. Its chemical properties and structural features can be explored to develop compounds with potential applications in the treatment of various diseases and conditions.
Used in Chemical Biology:
In chemical biology, Ethanone,1-(2-amino-5-chloro-4-fluorophenyl)is employed as a tool compound to probe the function and mechanisms of biological systems. Its interactions with proteins, enzymes, and other biomolecules can provide valuable insights into the underlying biology and help uncover new targets for therapeutic intervention.
Overall, Ethanone,1-(2-amino-5-chloro-4-fluorophenyl)is a versatile chemical compound with potential applications across various scientific disciplines. Its unique structure and properties make it a valuable asset in pharmaceutical research, organic synthesis, medicinal chemistry, drug discovery, and chemical biology. Further research and experimentation are essential to fully understand its potential and maximize its utility in these fields.

InChI:InChI=1/C8H7ClFNO/c1-4(12)5-2-6(9)7(10)3-8(5)11/h2-3H,11H2,1H3

Upstream product

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Relevant articles and documents

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A series of potent anthranilic acid-based inhibitors of the hepatitis C NS5B polymerase has been identified. The inhibitors bind to a site on NS5B between the thumb and palm regions adjacent to the active site as determined by X-ray crystallography of the enzyme-inhibitor complex. Guided by both molecular modeling and traditional SAR, the enzyme activity of the initial hit was improved by approximately 100-fold, yielding a series of potent and selective NS5B inhibitors with IC50 values as low as 10 nM. These compounds were also inhibitors of the HCV replicon in cultured HUH7 cells.