93799-60-1Relevant articles and documents
Biolabeling with 2,4-dichlorophenoxyacetic acid derivatives: The 2,4-D tag
Bade, Steffen,Roeckendorf, Niels,Franek, Milan,Gorris, Hans H.,Lindner, Buko,Olivier, Verena,Schaper, Klaus-Juergen,Frey, Andreas
, p. 9695 - 9702 (2009)
Many bioanalytic and diagnostic procedures rely on labels with which the molecule of interest can be tracked in or discriminated from accompanying like substances. Herein, we describe a new labeling and detection system based on derivatives of 2,4-dichlorophenoxyacetic acid (2,4-D) and anti-2,4-D antibodies. The 2,4-D system is highly sensitive witha KDof7×10 -11Mforthehapten-antibody pair, can be used on a large variety of biomolecules such as proteins, peptides, carbohydrates, and nucleic acids, is not hampered by endogenous backgrounds because 2,4-D is a xenobiotic, and is robust because 2,4-D is a very stable compound that withstands the conditions of most reactions usually performed on biomolecules. With this unique blend of properties, the 2,4-D system compares favorably with its rivals digoxigenin (DIG)/anti-DIG and biotin/(strept)avidin and provides an interesting and powerful tool in biomolecular labeling.
New antiarrhythmic agents. 2,2,5,5-tetramethyl-3-pyrroline-3-carboxamides and 2,2,5,5-tetramethylpyrrolidine-3-carboxamides
Hankovszky,Hideg,Bodi,Frank
, p. 1138 - 1152 (2007/10/02)
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