938-91-0Relevant academic research and scientific papers
Hydroxoiridium-Catalyzed Hydroalkylation of Terminal Alkenes with Ureas by C(sp3)?H Bond Activation
Yamauchi, Daisuke,Nishimura, Takahiro,Yorimitsu, Hideki
supporting information, p. 7200 - 7204 (2017/06/13)
Direct alkylation of a methyl group, on di- and trisubstituted ureas, with terminal alkenes by C(sp3)?H bond activation proceeded in the presence of a hydroxoiridium/bisphosphine catalyst to give high yields of the corresponding addition products. The hydroxoiridium/bisphosphine complex generates an amidoiridium intermediate by reaction with ureas having an N?H bond.
Rhodium catalyzed regioselective arene homologation of aryl urea via double C–H bond activation and migratory insertion of alkyne
Wang, Yan,Zhou, Hao,Xu, Ke,Shen, Mei-Hua,Xu, Hua-Dong
supporting information, p. 92 - 96 (2017/01/12)
A convenient rhodium catalyzed oxidative arene homologation of aniline derivatives with symmetrical or unsymmetrical alkynes using Cu(OAc)2as oxidant is described. Urea group is shown to be effective as a directing group for initial ortho C–H activation. Two migratory insertion events of alkyne into Rh–C bond occur successively, both with complete regioselectivity. This method is particularly useful for synthesis of polyarenes with different substituents, which has not been reported with conventional protocol. A mechanism has been proposed to explain the observed data.
Process for the preparation of urea derivatives
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, (2008/06/13)
A process for the preparation of a urea derivative having the formula: STR1 in which A represents a straight- or branched-chain alkyl group having 1-20 carbon atoms, an aryl group, or a heterocyclic group, and each of R1 and R2 represents hydrogen, a straight- or branched-chain alkyl group having 1-20 carbon atoms, an alicyclic group, or an aryl groups, which comprises: reacting sodium salt of an N-halogenamide with a quaternary ammonium salt to obtain its addition salt and then, reacting said addition salt with an amine derivative in the absence or presence of an organic solvent.
