938-97-6

Basic information

• Product Name: DL-4-HYDROXYPHENYLGLYCINE
• Synonyms: DL-4-OH-Phg-OH;(4-Hydroxyphenyl)(amino)acetic acid;2-(4-Hydroxyphenyl)glycine;2-amino-2-(4-hydroxyphenyl)acetic acid (en);4-[Amino(carboxy)methyl]phenol;4-[Amino(carboxy)methyl]phenol, Amino(4-hydroxyphenyl)acetic acid;DL-4-HYDROXYPHENYLGLYCINE;AMINO-(4-HYDROXY-PHENYL)-ACETIC ACID
• CAS NO: 938-97-6
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• EINECS: 228-682-7
• Product Categories: pharmacetical;Pharmaceutical Intermediates
• Mol File: 938-97-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 229-230 °C
• Boiling Point: 446.3 °C at 760 mmHg
• Flash Point: 223.7 °C
• Appearance: /
• Density: 1.411 g/cm³
• Vapor Pressure: 1.7E-06mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO (Very Slightly, Heated), Water (Slightly, Heated, Sonicated)
• PKA: 2.15±0.10(Predicted)
• CAS DataBase Reference: DL-4-HYDROXYPHENYLGLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-4-HYDROXYPHENYLGLYCINE(938-97-6)
• EPA Substance Registry System: DL-4-HYDROXYPHENYLGLYCINE(938-97-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 938-97-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 938-97-6 differently. You can refer to the following data:
1. (4-Hydroxyphenyl)glycine, is a key intermediate for the synthesis Cefpiramide (C243400), used as a β-lactam antibiotic.
2. 4-hydroxyphenylglycine is used (now only rarely) as a photographic developer and in the determination of phosphorus and silicon.

InChI:InChI=1/C8H15NO3/c9-7(8(11)12)5-1-3-6(10)4-2-5/h5-7,10H,1-4,9H2,(H,11,12)/t5?,6?,7-/m0/s1

Upstream product

• 6324-01-2 p-hydroxyphenylglycine 
• 64923-06-4 D-p-hydroxyphenylglycine o-toluenesulfonate 

Relevant articles and documents

The Optical Resolution and Asymmetric Transformation of DL-p-Hydroxyphenylglycine with (+)-1-Phenylethanesulfonic Acid

Optically active 1-phenylethanesulfonic acid was found to be an efficient resolving agent for the optical resolution and asymmetric transformation of DL-p-hydroxyphenylglycine.When DL-p-hydroxyphenylglycine was resolved by the fractional crystallization of its diastereomeric salt with (+)-1-phenylethanesulfonic acid, less soluble D-p-hydroxyphenylglycine (+)-1-phenylethanesulfonate was obtained in a good yield.Soluble L-HPG*(+)-PES was easily epimerized into DL-HPG*(+)-PES by heating it at 100 deg C in glacial acetic acid in the presence of a small amount of salicylaldehyde.Under such epimerizing conditions, the asymmetric transformation of DL-HPG*(+)-PES was attempted by simultaneously combining the fractional crystallization of the less soluble D-HPG*(+)-PES and the epimerization of the soluble L-HPG*(+)-PES.This asymmetric tranformation was achieved succesfully; that is, 80percent of the DL-HPG used as the starting material was converted into D-HPG.