938045-20-6Relevant articles and documents
Is samoquasine A indeed benzo[f]phthalazin-4(3H)-one? Unambiguous, straightforward synthesis of benzo[f]phthalazin-4(3H)-one and its regioisomer benzo[f]phthalazin-1(2H)-one
Monsieurs, Katrien,Tapolcsányi, Pál,Loones, Kristof T.J.,Neumajer, Gábor,Dirk De Ridder,Goubitz, Kees,Lemière, Guy L.F.,Dommisse, Roger A.,Mátyus, Péter,Maes, Bert U.W.
, p. 3870 - 3881 (2008/02/03)
In search for the structural elucidation of samoquasine A, a natural product isolated from the seeds of Annona squamosa L., two benzo[f]phthalazinone isomers have been synthesized. The synthetic pathway followed to build up these skeletons is based on the combination of two Suzuki reactions on a pyridazinone precursor and a ring closure reaction via a condensation reaction. 1H NMR data of the synthesized compound allowed to establish that the structure of the natural product samoquasine A is not benzo[f]phthalazin-4(3H)-one, as previously suggested.