938185-92-3Relevant articles and documents
Novel selective human melanocortin-3 receptor ligands: Use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold
Ballet, Steven,Mayorov, Alexander V.,Cai, Minying,Tymecka, Dagmara,Chandler, Kevin B.,Palmer, Erin S.,Rompaey, Karolien Van,Misicka, Aleksandra,Tourwe, Dirk,Hruby, Victor J.
, p. 2492 - 2498 (2007)
In search of new selective antagonists and/or agonists for the human melanocortin receptor subtypes hMC1R to hMC5R to elucidate the specific biological roles of each GPCR, we modified the structures of the superagonist MT-II (Ac-Nle-c[Asp-His-d-Phe-Arg-Tr
Azepinone-containing tetrapeptide analogues of melanotropin lead to selective h MC4R agonists and h MC5R antagonist
Van Der Poorten, Olivier,Fehér, Krisztina,Buysse, Koen,Feytens, Debby,Zoi, Ioanna,Schwartz, Steven D.,Martins, José C.,Tourwé, Dirk,Cai, Minying,Hruby, Victor J.,Ballet, Steven
, p. 192 - 197 (2015/03/04)
To address the need for highly potent, metabolically stable, and selective agonists, antagonists, and inverse agonists at the melanocortin receptor subtypes, conformationally constrained indolo- and benzazepinone residues were inserted into the α-MSH phar
