93820-08-7

Basic information

• Product Name: 3-chloro-2-hydroxybenzoyl chloride
• Synonyms: 3-chloro-2-hydroxybenzoyl chloride;Benzoyl chloride, 3-chloro-2-hydroxy- (9CI);3-Chloro-2-hydroxybenzoic acid chloride
• CAS NO: 93820-08-7
• Molecular Formula: C₇H₄Cl₂O₂
• Molecular Weight: 191.01146
• EINECS: 298-593-6
• Product Categories: ACIDHALIDE
• Mol File: 93820-08-7.mol

Chemical Properties

• Boiling Point: 256.6°Cat760mmHg
• Flash Point: 109°C
• Appearance: /
• Density: 1.513g/cm³
• Vapor Pressure: 0.00949mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: 3-chloro-2-hydroxybenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-2-hydroxybenzoyl chloride(93820-08-7)
• EPA Substance Registry System: 3-chloro-2-hydroxybenzoyl chloride(93820-08-7)

Safety Data

• Hazardous Substances Data: 93820-08-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H4Cl2O2/c8-5-3-1-2-4(6(5)10)7(9)11/h1-3,10H

Upstream product

• 1829-32-9 3-Chloro-2-hydroxybenzoic acid 
• 70771-66-3 sodium 3-chloro-2-hydroxybenzoate 

Downstream Products

• 29956-84-1 3-chloro-2-hydroxybenzamide 
• 1927-94-2 3-chlorosalicylaldehyde 
• 1314114-46-9 3-chloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide 

Relevant articles and documents

Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG)

The metabolism of poly(ADP-ribose) (PAR) in response to DNA strand breaks, which involves the concerted activities of poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribose) glycohydrolase (PARG), modulates cell recovery or cell death depending upon the level of DNA damage. While PARP inhibitors show high promise in clinical trials because of their low toxicity and selectivity for BRCA related cancers, evaluation of the therapeutic potential of PARG is limited by the lack of well-validated cell permeable inhibitors. In this study, target-related affinity profiling (TRAP), an alternative to high-throughput screening, was used to identify a number of druglike compounds from several chemical classes that demonstrated PARG inhibition in the low-micromolar range. A number of analogues of one of the most active chemotypes were synthesized to explore the structure-activity relationship (SAR) for that series. This led to the discovery of a putative pharmacophore for PARG inhibition that contains a modified salicylanilide structure. Interestingly, these compounds also inhibit PARP-1, indicating strong homology in the active sites of PARG and PARP-1 and raising a new challenge for development of PARG specific inhibitors. The cellular activity of a lead inhibitor was demonstrated by the inhibition of both PARP and PARG activity in squamous cell carcinoma cells, although preferential inhibition of PARG relative to PARP was observed. The ability of inhibitors to modulate PAR metabolism via simultaneous effects on PARPs and PARG may represent a new approach for therapeutic development.

SYNTHESIS OF ACYL CHLORIDES OF 3-CHLORO-, 5-CHLORO-, AND 3,5-DICHLORO-2-HYDROXYBENZOIC ACIDS.

Acyl halides of chloro-substituted hydroxybenzoic acids (CSHBA) are used as intermediates for production of amides, anilides, and esters having high pesticidal activity. The reactions of alkali salts of 3-chloro-, 5-chloro-, and 3,5-dichloro-2-hydroxybenzoic acids with thionyl chloride for synthesis of any chlorides were studied. The influence of temperature and initial component ratio was studied. On the basis of experimental results, optimal conditions are suggested.