1829-32-9

Basic information

• Product Name: 3-Chlorosalicylic acid
• Synonyms: 3-CHLORO-2-HYDROXYBENZOIC ACID;3-CHLOROSALICYLIC ACID;Salicylic acid, 3-chloro-;Benzoic acid, 3-chloro-2-hydroxy-;2-Hydroxy-3-chlorobenzoic acid;3-Chlorosalicylic acid,98%;NSC 18854;3-Chlorosalicylic acid 98%
• CAS NO: 1829-32-9
• Molecular Formula: C₇H₅ClO₃
• Molecular Weight: 172.57
• EINECS: 217-379-5
• Product Categories: Aromatics;C7;Carbonyl Compounds;Carboxylic Acids;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
• Mol File: 1829-32-9.mol
• Article Data: 22

Chemical Properties

• Melting Point: 184-186 °C(lit.)
• Boiling Point: 291.7 ºC at 760 mmHg
• Flash Point: 130.2 ºC
• Appearance: White/Crystalline Powder
• Density: 1.536 g/cm³
• Vapor Pressure: 0.000876mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: 2.43±0.10(Predicted)
• CAS DataBase Reference: 3-Chlorosalicylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chlorosalicylic acid(1829-32-9)
• EPA Substance Registry System: 3-Chlorosalicylic acid(1829-32-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 1829-32-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

3-Chlorosalicylic Acid (cas# 1829-32-9) is a compound useful in organic synthesis.

General Description

The photocatalytic degradation of 3-chlorosalicylic acid (3-CSA) by pure and Nb-doped TiO2 ceramic membranes was studied.

InChI:InChI=1/C7H5ClO3/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,9H,(H,10,11)/p-1

Synthetic route

3-chloro-2-hydroxy-thiobenzoic acid S-methyl ester (116025-20-8) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With lithium hydroxide In methanol at 20℃; for 6h;	100%

carbon dioxide (124-38-9) + chloro-1 methoxymethylenoxy-2 benzene (27701-22-0) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
Stage #1: chloro-1 methoxymethylenoxy-2 benzene With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1.5h; Stage #2: carbon dioxide In tetrahydrofuran; hexane at -78℃; for 1.5h; Stage #3: With hydrogenchloride In tetrahydrofuran; hexane at 20℃;	91%

2,3-dichlorbenzoic acid (50-45-3) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With pyridine; copper; potassium carbonate In water for 2h; Heating;	85%
With copper(l) iodide; copper; potassium carbonate at 180℃; under 7355.08 Torr;

N-(4-fluorophenyl)glycine potassium salt → 3-Chloro-2-hydroxybenzoic acid (1829-32-9) + N-(4-fluorophenyl)-N-(2-carboxyphenyl)glycin (180911-99-3)

Conditions	Yield
Stage #1: N-(4-fluorophenyl)glycine potassium salt With potassium 2,5-dichlorobenzoate; copper; potassium carbonate In water for 20.5h; Heating / reflux; Stage #2: With hydrogenchloride In water at 75 - 80℃; for 0.5h;	A n/a B 80.3%

2-monochlorophenol (95-57-8) + sodium ethyl carbonate (17201-44-4) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With carbon dioxide at 190℃; under 7600.51 Torr; for 6h; Autoclave; regioselective reaction;	68.2%

carbon dioxide (124-38-9) + 2-monochlorophenol (95-57-8) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
Stage #1: 2-monochlorophenol With Mesitol; sodium hydride In mineral oil at 100℃; for 0.0833333h; Glovebox; Stage #2: carbon dioxide In mineral oil at 185℃; under 3800.26 Torr; for 2h;	55%
With potassium carbonate at 170℃; under 29420.3 Torr;

3-chloro-2-hydroxy-benzoic acid-(2,2,2-trichloro-1-hydroxy-ethylamide) (873975-79-2) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With sodium hydroxide

salicylic acid disodium salt (54-21-7, 13639-21-9, 79211-80-6) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With sodium hypochlorite

5-sulfosalicylic Acid (97-05-2) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With chlorine; acetic acid Behandeln des Reaktionsprodukts mit ueberhitztem Wasserdampf;
With hydrogenchloride; potassium permanganate Behandeln des Reaktionsprodukts mit ueberhitztem Wasserdampf;

tetrachloromethane (56-23-5) + tert-butylhypochlorite (507-40-4) + salicylic acid (69-72-7) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

tert-butylhypochlorite (507-40-4) + salicylic acid (69-72-7) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With tetrachloromethane

salicylic acid (69-72-7) → 5-chloro-2-hydroxybenzoic acid (321-14-2) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With sodium carbonate bei der Chlorierung;
With sodium hydroxide; sodium hypochlorite at 20℃; for 2.5h; pH > 12; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With N-chlorotriethylammonium chloride In trifluoroacetic acid Ambient temperature; Yield given. Yields of byproduct given;

3-chlorosalicylaldehyde (1927-94-2) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With sodium hydroxide; potassium permanganate Heating;

2-amino-3-chlorobenzoic acid (6388-47-2) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With copper(II) sulfate 1.) diazotized; Yield given. Multistep reaction;

dipotassium 5-chlorosalicyl sulphate → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With HCl-chloroacetate; potassium chloride at 70℃; Rate constant; dependence on pH;

7-chloro-1,1-dioxo-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one (89999-91-7) + water (7732-18-5) + sodium hydroxide → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
beim Schmelzen;

chlorine (7782-50-5) + acetic acid (64-19-7) + 5-sulfosalicylic Acid (97-05-2) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
Behandeln des Reaktionsprodukts mit Wasserdampf;

carbon dioxide (124-38-9) + 2-chloro-phenol sodium → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
at 140 - 150℃; im Autoklaven;

2-hydroxy-1-carboxy-benzenediazonium-(3)-betaine → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With hydrogenchloride Sonnenlicht;

sodium salicylate (54-21-7) + chlorine (7782-50-5) + natrium carbonate → 5-chloro-2-hydroxybenzoic acid (321-14-2) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

3-chloro-2-methoxymethoxy-benzoic acid → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With hydrogenchloride In water pH=1;	3.19 g

3-chlorobenzoate (535-80-8) → 5-chloro-2-hydroxybenzoic acid (321-14-2) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
Stage #1: 3-chlorobenzoate With [bis(acetonitrile)(N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)-1,2-diaminoethane)iron(II)] perchlorate; dihydrogen peroxide In acetonitrile at 20℃; for 0.333333h; Stage #2: With hydrogenchloride In acetonitrile
With [Fe(II)(N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)-1,2-ethylenediamine)(CH3CN)2](ClO4)2; dihydrogen peroxide In water; acetonitrile at 20℃; Inert atmosphere; regioselective reaction;

chloro-1 methoxymethylenoxy-2 benzene (27701-22-0) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: butyllithium / tetrahydrofuran; hexane / 6 h / -75 °C 1.2: tetrahydrofuran; hexane 2.1: 3.19 g / HCl / H2O / pH 1 View Scheme

2-monochlorophenol (95-57-8) + (+-)-ethylphosphonic acid ethyl ester chloride → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: BCl3; AlCl3 / 1,2-dichloro-ethane / 4 h / 20 °C 1.2: 51 percent / aq. HCl / 1,2-dichloro-ethane / 0.17 h / 20 °C 2.1: 100 percent / aq. LiOH / methanol / 6 h / 20 °C View Scheme

2-monochlorophenol (95-57-8) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 96 percent / NaH / tetrahydrofuran; methyl acetate / 2 h / 0 - 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / 0 °C 2.2: tetrahydrofuran; hexane / 1.5 h / -78 °C 2.3: 91 percent / 6M HCl / tetrahydrofuran; hexane / 20 °C View Scheme
Multi-step reaction with 2 steps 1: (i) aq. NaOH, (ii) /BRN= 1731042/ 2: KMnO4, aq. NaOH / Heating View Scheme
Multi-step reaction with 4 steps 1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: water; sodium hydrogencarbonate / N,N-dimethyl-formamide; diethyl ether / 0.5 h / 20 °C / Inert atmosphere 3.1: palladium diacetate; silver(I) acetate; N-tert-butoxycarbonyl-L-leucine; 2,2,2-trifluoroethanol / 1,2-dichloro-ethane / 0.08 h / 95 °C / Inert atmosphere 3.2: 18 h / 95 °C / Inert atmosphere 3.3: 18 h / 95 °C / Inert atmosphere; Glovebox 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / Inert atmosphere View Scheme

3-chloro-2-nitro-benzoic acid (4771-47-5) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: 72 percent / tin, hydrochloric acid 2: 2.) CuSO4 / 1.) diazotized View Scheme

potassium 2,5-dichlorobenzoate + N-(4-fluorophenyl)glycine potassium salt → N-(4-fluorophenyl)-N-(2-carboxy-4-chlorophenyl)glycine + 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With potassium carbonate; copper In water at 50℃; for 15 - 20.5h; Heating / reflux; Industry scale;

2-monochlorophenol (95-57-8) + potassium hydrogencarbonate (298-14-6) → 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With 2,3-dihydroxybenzoate decarboxylase from Aspergillus oryzae In aq. phosphate buffer at 30℃; for 24h; Kolbe-Schmidt Synthesis; Enzymatic reaction; regioselective reaction;

salicylic acid (69-72-7) → 5-chloro-2-hydroxybenzoic acid (321-14-2) + 3,5-dichlorosalicylic acid (320-72-9) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9)

Conditions	Yield
With sodium hypochlorite In methanol; water

3-Chloro-2-hydroxybenzoic acid (1829-32-9) + methyl iodide (74-88-4) → methyl 3-chloro-2-methoxybenzoate

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 80℃; for 23h;	100%
With potassium carbonate In N-methyl-acetamide

formaldehyd (50-00-0) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9) → 3,3'-dicarboxy-5,5'-dichloro-4,4'-dihydroxydiphenylmethane (128626-47-1)

Conditions	Yield
With sulfuric acid In methanol; water 1.)0 deg C, 1h 2.) r. t., 24h;	96%
With sulfuric acid In methanol; water at -5 - 0℃; for 24.3333h;	92%
With sulfuric acid; water In methanol at -5 - 20℃; for 26h;	92%

3-Chloro-2-hydroxybenzoic acid (1829-32-9) + 2-amino-benzenethiol (137-07-5) → 2-(2'-Hydroxy-3'-chlorophenyl)benzothiazole (90481-39-3)

Conditions	Yield
With phosphorus trichloride In toluene for 4h; Heating;	94%
With phosphorus trichloride In toluene at 100℃;	45%

2,2,2-trifluoroethanol (75-89-8) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9) → C9H6ClF3O3

Conditions	Yield
With thionyl chloride for 6h; Inert atmosphere; Reflux;	82%

2-iodo-propane (75-30-9) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9) → 3-chloro-2-isopropoxybenzoic acid isopropyl ester (894851-25-3)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 66h;	77%

3-Chloro-2-hydroxybenzoic acid (1829-32-9) + acetic anhydride (108-24-7) → 2-(acetylocy)-3-chlorobenzoic acid (16534-19-3)

Conditions	Yield
Stage #1: 3-Chloro-2-hydroxybenzoic acid; acetic anhydride With triethylamine In tetrahydrofuran at 20℃; for 22.5h; Stage #2: With hydrogenchloride In water	76%
With sulfuric acid at 140℃; for 2h;	43%
With sulfuric acid
With sulfuric acid In water at 20℃; Heating;

3-aminoquinoline (580-17-6) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9) → 3-chloro-2-hydroxy-N-(quinolin-3-yl)benzamide (1257883-68-3)

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 40℃; for 8h;	76%

3-Chloro-2-hydroxybenzoic acid (1829-32-9) + 1,2-diamino-benzene (95-54-5) → 2-(2'-Hydroxy-3'-chlorophenyl)benzimidazole (96459-82-4)

Conditions	Yield
With PPA at 150℃;	75%

orcinol (504-15-4) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9) → 5-chloro-1-hydroxy-3-methyl-9H-xanthen-9-one

Conditions	Yield
With methanesulfonic acid; phosphorus pentoxide at 90℃;	71%

2-(4-pyridylmethylene amino) ethanol (106782-22-3) + Cyclohexyl isocyanide (931-53-3) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9) → C22H26ClN3O4 (917890-17-6)

Conditions	Yield
With 3 A molecular sieve In methanol at 20℃; Ugi reaction;	64%

Cyclohexyl isocyanide (931-53-3) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9) + (E)-2-(benzylideneamino)ethanol (124948-51-2) → C23H27ClN2O4 (917890-16-5)

Conditions	Yield
With 3 A molecular sieve In methanol at 20℃; Ugi reaction;	63%

3-Chloro-2-hydroxybenzoic acid (1829-32-9) + 3,5-Bis-(trifluoromethyl)aniline (328-74-5) → N-(3,5-bis-trifluoromethyl-phenyl)-3-chloro-2-hydroxy-benzamide

Conditions	Yield
With pyridine; phosphorus trichloride In toluene Inert atmosphere; Reflux;	59%
With phosphorus trichloride In toluene Inert atmosphere; Reflux;	24%
With phosphorus trichloride In 5,5-dimethyl-1,3-cyclohexadiene for 5h; Reflux;

3-Chloro-2-hydroxybenzoic acid (1829-32-9) + propyl bromide (106-94-5) → 3-chloro-2-propoxybenzoic acid propyl ester (894851-30-0)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 30℃; for 66h;	51%

3-Chloro-2-hydroxybenzoic acid (1829-32-9) + ethyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate (141104-65-6) → 2-(3-chloro-2-hydroxy-benzoylamino)-indan-2-carboxylic acid ethyl ester (1092447-22-7)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃;	49%

3-Chloro-2-hydroxybenzoic acid (1829-32-9) + methyl 3-((4-acetylpiperazin-1-yl)methyl)benzoate → methyl 3-((4-(8-chloro-4-oxochromen-2-yl)piperazin-1-yl)methyl)benzoate

Conditions	Yield
Stage #1: methyl 3-[(4-acetylpiperazin-1-yl)methyl]benzoate With trichlorophosphate In dichloromethane at 0 - 25℃; for 1h; Stage #2: 3-Chloro-2-hydroxybenzoic acid In dichloromethane at 0 - 60℃; for 15h; Stage #3: With sodium acetate In dichloromethane at 60℃; for 4h;	48.4%

C20H15N2PS2 (89430-08-0) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9) → 8-chloro-2-thioxo-2,3-dihydro-4H-1,3-benzoxazin-4-one

Conditions	Yield
In dichloromethane	48%

tert-Octylamine (107-45-9) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9) → 3-chloro-2-hydroxy-N-(2,4,4-trimethylpentan-2-yl)benzamide

Conditions	Yield
Stage #1: 3-Chloro-2-hydroxybenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.25h; Inert atmosphere; Stage #2: tert-Octylamine In N,N-dimethyl-formamide at 0 - 20℃; for 16h;	43.08%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 16h; Inert atmosphere;	36.58%

perfluoro-2-methylpent-2-ene (1584-03-8) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9) → 4-(F-ethyl)-3-(F-methyl)-10-chloro-2H,6H-1,5-benzodioxocin-2,6-dione

Conditions	Yield
With triethylamine In acetonitrile for 5h; Ambient temperature;	41%

3-Chloro-2-hydroxybenzoic acid (1829-32-9) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 3-chloro-5-nitrosalicylate (337520-41-9)

Conditions	Yield
With sulfuric acid; nitric acid In methanol; hexane; benzene	39%

3-nitro-5-(trifluoromethyl)-phenylamine (401-94-5) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9) → 3-chloro-2-hydroxy-N-(3-nitro-5-(trifluoromethyl)phenyl)benzamide

Conditions	Yield
With phosphorus trichloride In 5,5-dimethyl-1,3-cyclohexadiene for 5h; Reflux;	39%

3-Chloro-2-hydroxybenzoic acid (1829-32-9) + 3,5-dimethylaminoaniline (108-69-0) → 3-chloro-N-(3,5-dimethylphenyl)-2-hydroxybenzamide

Conditions	Yield
With phosphorus trichloride In toluene Inert atmosphere; Reflux;	27%

1-[4-(3-aminophenyl)piperazin-1-yl]-2-(5-methyl-3-trifluoromethylpyrazol-1-yl)ethanone (1392267-89-8) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9) → 3-chloro-2-hydroxy-N-(3-{4-[2-(5-methyl-3-trifluoromethylpyrazol-1-yl)acetyl]piperazin-1-yl}phenyl)benzamide (1392267-90-1)

Conditions	Yield
Stage #1: 3-Chloro-2-hydroxybenzoic acid With 1,1'-carbonyldiimidazole In acetonitrile at 60℃; for 2h; Stage #2: 1-[4-(3-aminophenyl)piperazin-1-yl]-2-(5-methyl-3-trifluoromethylpyrazol-1-yl)ethanone With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 60℃;	26%
Stage #1: 3-Chloro-2-hydroxybenzoic acid With 1,1'-carbonyldiimidazole In acetonitrile at 60℃; for 2h; Stage #2: 1-[4-(3-aminophenyl)piperazin-1-yl]-2-(5-methyl-3-trifluoromethylpyrazol-1-yl)ethanone With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 60℃;

2-amino-6-bromobenzothiazole (15864-32-1) + 3-Chloro-2-hydroxybenzoic acid (1829-32-9) → 3-chloro-N-(6-bromo-1,3-benzothiazol-2-yl)-2-hydroxybenzamide

Conditions	Yield
Stage #1: 3-Chloro-2-hydroxybenzoic acid With phosphorus trichloride In chlorobenzene for 0.5h; Reflux; Stage #2: 2-amino-6-bromobenzothiazole In chlorobenzene for 4h; Reflux;	26%

(1R)-5-chloroindan-1-amine + 3-Chloro-2-hydroxybenzoic acid (1829-32-9) → C16H13Cl2NO2

Conditions	Yield
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 12h;	21%

Upstream product

• 7782-50-5 chlorine 
• 64-19-7 acetic acid 
• 97-05-2 5-sulfosalicylic Acid 
• 1927-94-2 3-chlorosalicylaldehyde 
• 95-57-8 2-monochlorophenol 
• 17201-44-4 sodium ethyl carbonate 
• 27701-22-0 chloro-1 methoxymethylenoxy-2 benzene 
• 535-80-8 3-chlorobenzoate 
• 116025-20-8 3-chloro-2-hydroxy-thiobenzoic acid S-methyl ester 
• 124-38-9 carbon dioxide 
• 54-21-7 sodium salicylate 
• 89999-91-7 7-chloro-1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one 
• 7732-18-5 water 
• 6388-47-2 2-amino-3-chlorobenzoic acid 

Downstream Products

• 894851-25-3 3-chloro-2-isopropoxybenzoic acid isopropyl ester 
• 90481-39-3 2-(2'-Hydroxy-3'-chlorophenyl)benzothiazole 
• 128626-47-1 3,3'-dichloro-5,5'-dicarboxy-4,4'-dihydroxydiphenylmethane 
• 93820-08-7 3-chloro-2-hydroxybenzoyl chloride 
• 1927-94-2 3-chlorosalicylaldehyde 
• 95-57-8 2-monochlorophenol 
• 52159-67-8 methyl 3-chloro-2-hydroxybenzoate 

Relevant articles and documents

Carboxylation of o-, m-, and p-chlorophenols with sodium ethyl carbonate

The possibility for the synthesis of 5-chloro-2-hydroxybenzoic, 4-chloro-2-hydroxybenzoic, and 3-chloro-2-hydroxybenzoic acids via regioselective carboxylation of p-, m-, and o-chlorophenols, respectively, with sodium ethyl carbonate has been demonstrated

Synthesis of salicylic acid derivatives from the corresponding 2-chlorobenzoic acid using water as solvent

An improved synthesis of salicylic acid using water as solvent can be achieved using the Ullmann-Goldberg reaction conditions in presence of pyridine as cocatalyst. A number of salicylic acids were prepared in good yield.

Carboxylation of Phenols with CO2 at Atmospheric Pressure

A convenient and efficient method for the ortho-carboxylation of phenols under atmospheric CO2 pressure has been developed. This method provides an alternative to the previously reported Kolbe-Schmitt method, which requires very high pressures of CO2. The addition of a trisubstituted phenol has proved essential for the successful carboxylation of phenols with CO2 at standard atmospheric pressure, allowing the efficient preparation of a broad variety of salicylic acids.

General method for the synthesis of salicylic acids from phenols through palladium-catalyzed silanol-directed C-H carboxylation

A silanol-directed, palladium-catalyzed C-H carboxylation reaction of phenols to give salicylic acids has been developed. This method features high efficiency and selectivity, and excellent functional-group tolerance. The generality of this method was demonstrated by the carboxylation of estrone and by the synthesis of an unsymmetrically o,o′-disubstituted phenolic compound through two sequential C-H functionalization processes.