93824-72-7

Usage

InChI:InChI=1/C7H6ClN3/c1-4-5(2)10-11-7(8)6(4)3-9/h1-2H3

Upstream product

• 40380-36-7 5,6-dimethyl-3-oxo-2,3-dihydropyridazine-4-carbonitrile 

Downstream Products

• 93824-73-8 5,6-dimethyl-3-(phenylthio)pyridazine-4-carbonitrile 
• 1451993-08-0 5-amino-4-methyl-3-(morpholinomethyl)-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno[2,3-c]pyridazine-6-carboxamide 
• 1451993-15-9 5-amino-3,4-dimethyl-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno-[2,3-c]pyridazine-6-carboxamide 
• 1451996-23-8 C₁₇H₁₆F₂N₄O₂S 
• 1451994-72-1 5-amino-N-(3-fluoro-4-hydroxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide 
• 1451993-40-0 5-amino-N-(4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide 
• 1451994-15-2 C₁₆H₁₆N₄O₂S 
• 1451994-10-7 5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide 
• 1451997-78-6 C₁₇H₁₇FN₄O₂S 
• 1451993-12-6 5-amino-N-(4-(2-fluoropyridine-3-yl)benzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide 
• 1451993-13-7 5-amino-N-(4-bromobenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide 
• 1452226-14-0 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and Preliminary Evaluation of 11C-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4

Muscarinic acetylcholine receptors (mAChRs) have five distinct subunits (M1–M5) and are involved in the action of the neurotransmitter acetylcholine in the central and peripheral nervous system. Attributed to the promising clinical efficacy of xanomeline, an M1/M4-preferring agonist, in patients of schizophrenia and Alzheimer's disease, M1- or M4-selective mAChR modulators have been developed that target the topographically distinct allosteric sites. Herein we report the synthesis and preliminary evaluation of 11C-labeled positron emission tomography (PET) ligands based on a validated M4R positive allosteric modulator VU0467485 (AZ13713945) to facilitate drug discovery. [11C]VU0467485 and two other ligands were prepared in high radiochemical yields (>30 %, decay-corrected) with high radiochemical purity (>99 %) and high molar activity (>74 GBq μmol?1). In vitro autoradiography studies indicated that these three ligands possess moderate-to-high in vitro specific binding to M4R. Nevertheless, further physiochemical property optimization is necessary to overcome the challenges associated with limited brain permeability.

Synthesis and reactions of some new thieno[2,3-c]pyridazine derivatives

The alkylation of 4-cyano-5,6-dimethylpyridazin-3(2H)-thione 3 with some halo compounds gave the S-alkylated products 4a-c, which upon treatment with ethanolic sodium ethoxide afforded the cyclized thienopyridazines 5a-c as products. Pyridazothienotriazin