93832-27-0Relevant academic research and scientific papers
Studies toward the Synthesis of Oximidines I and II
Haack, Torsten,Kurtkaya, Serdar,Snyder, James P.,Georg, Gunda I.
, p. 5019 - 5022 (2007/10/03)
(Equation presented) The synthesis of compound 1, a precursor for the synthesis of the oximidine II core structure 2, is described. An undesired C8-C9 isomerization occurred during the intramolecular Castro-Stephens reaction leading to macrocyle 3. The th
Synthesis of Functionalized Hydroxyphthalides and Their Conversion to 3-Cyano-1(3H)-isobenzofuranones. The Diels-Alder Reaction of Methyl 4,4-Diethoxybutynoate and Cyclohexadienes
Freskos, John N.,Morrow, Gary W.,Swenton, John S.
, p. 805 - 810 (2007/10/02)
Several methods have been used in the preparation of functionalized hydroxyphthalides.Metalation of N,N-diethyl-3-methoxybenzamide, followed by reaction with dimethylformamide and hydrolysis, furnished 3-hydroxy-4-methoxy-1(3H)-isobenzofuranone in 52perce
A Convenient Synthesis of Hydroxyphthalides
Freskos, John,Cynkowski, Tadeusz,Swenton, John S.
, p. 819 - 820 (2007/10/02)
The Diels-Alder reaction of in situ generated cyclohexa-1,3-dienes with methyl 4,4-diethoxybut-2-ynoate (1) followed by reverse Diels-Alder and hydrolysis affords substituted hydroxyphthalides in good yield.
