938374-55-1

Basic information

• Product Name: 2-(p-tolyl)-1H-indole-3-carbonitrile
• Synonyms: 2-(p-tolyl)-1H-indole-3-carbonitrile
• CAS NO: 938374-55-1
• Molecular Weight: 232.285
• Mol File: 938374-55-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(p-tolyl)-1H-indole-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(p-tolyl)-1H-indole-3-carbonitrile(938374-55-1)
• EPA Substance Registry System: 2-(p-tolyl)-1H-indole-3-carbonitrile(938374-55-1)

Safety Data

• Hazardous Substances Data: 938374-55-1(Hazardous Substances Data)

Upstream product

• 610-66-2 2-nitro-benzeneacetonitrile 
• 104-87-0 4-methyl-benzaldehyde 
• 19472-74-3 2-(2-bromophenyl)acetonitrile 
• 213599-19-0 1-bromo-2-(2,2-dibromovinyl)benzene 
• 5720-05-8 4-methylphenylboronic acid 

Relevant articles and documents

Synthesis of 3-Cyano-1H-indoles and Their 2′-Deoxyribonucleoside Derivatives through One-Pot Cascade Reactions

An efficient and economical synthetic approach toward 3-cyano-1H-indoles through the reactions of 2-(2-bromophenyl)acetonitriles with aldehydes and aqueous ammonia is presented. Mechanically, this novel protocol involves a one-pot cascade procedure consisting of an aldol-type condensation, a copper-catalyzed amination by using aqueous ammonia as a cheap and safe nitrogen source, and an intramolecular Michael addition followed by a dehydrogenative aromatization. Interestingly, the indole products thus obtained were found to be ready substrates for the preparation of indole 2′-deoxyribonucleosides through an unprecedented and highly practical glycosylation procedure in which the required C-N bond formation and toluoyl protecting group removal were accomplished efficiently in one pot.

Mn(III)-Mediated Radical Cyclization of o-Alkenyl Aromatic Isocyanides with Boronic Acids: Access to N-Unprotected 2-Aryl-3-cyanoindoles

The synthesis of N-unprotected 2-aryl-3-cyanoindoles was realized via the Mn(III)-mediated radical cascade cyclization of o-alkenyl aromatic isocyanides with boronic acids. A possible mechanism involving a sequential intermolecular radical addition, intramolecular cyclization, and cleavage of the C-C bond under mild reaction conditions is proposed. Mechanism studies show that H2O or O2 might provide the oxygen source for the elimination of benzaldehyde.

A 3 - cyano indole synthetic method of the compound

The invention discloses a method for synthesizing a 3-cyanoindole compound and belongs to the technical field of synthetic technology. The technical solution provided by the invention is characterized that the method for synthesizing the 3-cyanoindole com