93844-96-3Relevant academic research and scientific papers
ANTAGONISTS OF GPR39 PROTEIN
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Page/Page column 197-198, (2021/11/06)
Novel compounds that act as antagonists to human GPR39 protein are disclosed. Pharmaceutical compositions and methods of use for antagonists to human GPR39 protein are disclosed. In particular, methods of using the antagonists in the treatment of diseases or conditions including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases are disclosed herein.
Adjacent-ring directed ortho metallation by the 2-pyridyl group in 2-pyridyldiazines
Berghian, Camelia,Dǎrǎbantu, Mircea,Plé, Nelly,Turck, Alain
, p. 41 - 46 (2007/10/03)
The first examples demonstrating the aptitude of 2-pyridyl group substituting diazines as Directing ortho-Metallation Group (DoMG) are described: three 2-pyridyldiazines were deuteriated via metallation with lithium-2,2,6,6-tetramethylpiperidide (LTMP) indicating promising ortho regioselectivities with respect to the Ar-Ar bond on the diazine ring.
Metallation of pyridin-2-yldiazines. Use of pyridine ring as ortho-directing group. Diazines. Part 45
Berghian, Camelia,Darabantu, Mircea,Turck, Alain,Plé, Nelly
, p. 9637 - 9644 (2007/10/03)
Starting from commercial chlorodiazines, we report the synthesis of pyridin-2-yldiazines. The first lithiation and functionalization of these compounds are reported and the regioselectivity of the metallation is discussed. The functionalization via the metallation reaction, provides a new access to substituted pyridin-2-yldiazines, which could be used as building blocks in supramolecules.
PHOTOCHEMICAL ARYLATION BY OXIME ESTERS IN BENZENE AND PYRIDINE: SIMPLE SYNTHESIS OF BIARYL COMPOUNDS
Hasebe, Masato,Kogawa, Koichi,Tsuchiya, Takashi
, p. 3887 - 3890 (2007/10/02)
Irradiation of benzophenone O-arenecarbonyloximes in benzene and pyridine affords the corresponding arylbenzenes and arylpyridines, respectively, in high yields.
