93844-98-5

Usage

Uses

Used in Pharmaceutical Industry:
2-(pyridin-4-yl)pyrazine is used as a pharmaceutical intermediate for its potential therapeutic properties. It is being studied for its biological activity, which may contribute to the development of new drugs and therapeutic agents.
Used in Chemical Industry:
In the chemical industry, 2-(pyridin-4-yl)pyrazine is utilized as a building block in the synthesis of other organic compounds. Its unique structure allows for the creation of a wide range of chemical products, expanding its applications in various chemical processes.
Used in Drug Discovery and Development:
2-(pyridin-4-yl)pyrazine is employed as a key component in drug discovery and development. Its potential applications in this field are attributed to its biological activity, which may lead to the identification of novel therapeutic agents and contribute to advancements in medicinal chemistry.

Upstream product

• 110-86-1 pyridine 
• 93845-13-7 C₁₈H₁₃N₃O₂ 
• 56423-63-3 2-bromopyrazine 
• 1692-15-5 4-pyridylboronic acid 
• 14508-49-7 2-chloropyrazin 

Relevant academic research and scientific papers

Solvent-free, palladium-catalyzed Suzuki-Miyaura cross-couplings of aryl chlorides with arylboronic acids

Pd(MeCN)2Cl2/PCy3 was found to be an efficient catalytic system for the Suzuki-Miyaura cross-couplings of aryl chlorides with arylboronic acids under solvent-free conditions. Furthermore, the presence of the conventional solvents had deleterious effect on the reaction. In the presence of Pd(MeCN)2Cl2, PCy3, and TBAF (tetra-n-butylammonium fluoride), a number of aryl chlorides including heteroaryl chlorides were coupled with arylboronic acids or heteroarylboronic acids smoothly to afford the corresponding products in moderate to excellent yields. Copyright Taylor & Francis Group, LLC.

Mild and ligand-free palladium-catalyzed cross-couplings between aryl halides and arylboronic acids for the synthesis of biaryls and heterocycle-containing biaryls

Ligand-free palladium-catalyzed Suzuki-Miyaura cross-couplings between aryl halides and arylboronic acids performed at room temperature are presented. It was found that both solvent and base had a fundamental influence on the reaction, and the most effective system in terms of yield and rate was observed to be the combination of Pd(OAc)2 with MeONa and alcohols. In the presence of Pd(OAc)2 and MeONa, a variety of aryl halides reacted very rapidly with arylboronic acids in good to excellent yields at room ternperature in EtOH as the solvent. Moreover, the Pd(OAc)2/MeONa catalytic system could also be applied in couplings between heteroaryl halides and arylboronic acids to provide satisfactory results in MeOH as the solvent after prolonged reaction times. It is noteworthy that the reactions were conducted under mild, aerobic, and ligand-free conditions. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Pd(OAc)2/DABCO-catalyzed Suzuki-Miyaura cross-coupling reaction in DMF

The scope and limitations of the Pd(OAc)2/DABCO (1,4-diaza-bicyclo[2.2.2]octane)-catalyzed Suzuki-Miyaura cross-coupling reactions have been demonstrated. The results showed that the effect of solvent had a fundamental influence on the reaction. In the presence of Pd(OAc)2 and DABCO, both aryl bromides and aryl chlorides all worked well with arylboronic acids to form biaryls, heteroaryl-aryls, and biheteroaryls in moderate to excellent yields using DMF as the solvent. Additionally, the reactions of aryl bromides were conducted under relatively mild conditions.

PHOTOCHEMICAL ARYLATION BY OXIME ESTERS IN BENZENE AND PYRIDINE: SIMPLE SYNTHESIS OF BIARYL COMPOUNDS

Irradiation of benzophenone O-arenecarbonyloximes in benzene and pyridine affords the corresponding arylbenzenes and arylpyridines, respectively, in high yields.