93848-81-8 Usage
Description
N-Fomyl Amlodipine is a chemical compound closely related to amlodipine, a well-known calcium channel blocker utilized for the management of high blood pressure and angina. It shares a similar molecular structure with amlodipine, but is distinguished by the presence of a formyl group attached to the nitrogen atom. This structural alteration may influence the compound's pharmacological characteristics, including its potency, efficacy, and pharmacokinetic behavior. Further investigation is required to determine the comparative advantages and disadvantages of N-Fomyl Amlodipine in cardiovascular therapy.
Uses
Used in Pharmaceutical Industry:
N-Fomyl Amlodipine is used as a potential therapeutic agent for cardiovascular conditions due to its structural resemblance to amlodipine, a recognized calcium channel blocker. The addition of the formyl group may enhance or alter its pharmacological properties, offering new avenues for the treatment of high blood pressure and chest pain. However, more research is necessary to establish its safety, efficacy, and optimal dosage in clinical settings.
Check Digit Verification of cas no
The CAS Registry Mumber 93848-81-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,8,4 and 8 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 93848-81:
(7*9)+(6*3)+(5*8)+(4*4)+(3*8)+(2*8)+(1*1)=178
178 % 10 = 8
So 93848-81-8 is a valid CAS Registry Number.
93848-81-8Relevant articles and documents
Highly Efficient and Selective N-Formylation of Amines with CO2 and H2 Catalyzed by Porous Organometallic Polymers
Shen, Yajing,Zheng, Qingshu,Chen, Zhe-Ning,Wen, Daheng,Clark, James H.,Xu, Xin,Tu, Tao
supporting information, p. 4125 - 4132 (2021/01/12)
The valorization of carbon dioxide (CO2) to fine chemicals is one of the most promising approaches for CO2 capture and utilization. Herein we demonstrated a series of porous organometallic polymers could be employed as highly efficient and recyclable catalysts for this purpose. Synergetic effects of specific surface area, iridium content, and CO2 adsorption capability are crucial to achieve excellent selectivity and yields towards N-formylation of diverse amines with CO2 and H2 under mild reaction conditions even at 20 ppm catalyst loading. Density functional theory calculations revealed not only a redox-neutral catalytic pathway but also a new plausible mechanism with the incorporation of the key intermediate formic acid via a proton-relay process. Remarkably, a record turnover number (TON=1.58×106) was achieved in the synthesis of N,N-dimethylformamide (DMF), and the solid catalysts can be reused up to 12 runs, highlighting their practical potential in industry.
