938524-31-3Relevant academic research and scientific papers
Quest for a potent antimalarial drug lead: Synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines
Mizukawa, Yuki,Ikegami-Kawai, Mayumi,Horiuchi, Masako,Kaiser, Marcel,Kojima, Masayoshi,Sakanoue, Seiki,Miyagi, Seiya,Nanga Chick, Christian,Togashi, Hiroyuki,Tsubuki, Masayoshi,Ihara, Masataka,Usuki, Toyonobu,Itoh, Isamu
, (2021)
Quinazolines have long been known to exert varied pharmacologic activities that make them suitable for use in treating hypertension, viral infections, tumors, and malaria. Since 2014, we have synthesized approximately 150 different 6,7-dimethoxyquinazoline-2,4-diamines and evaluated their antimalarial activity via structure-activity relationship studies. Here, we summarize the results and report the discovery of 6,7-dimethoxy-N4-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine (20, SSJ-717), which exhibits high antimalarial activity as a promising antimalarial drug lead.
QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES
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Paragraph 0048-0049, (2014/03/25)
This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll-like-receptors is involved.
QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES
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Page/Page column 10, (2012/12/13)
This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll - like - receptors is involved.
