93860-66-3

Basic information

• Product Name: O,N-diacetylnorephedrine
• Synonyms: O,N-diacetylnorephedrine
• CAS NO: 93860-66-3
• Molecular Weight: 235.283
• Mol File: 93860-66-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: O,N-diacetylnorephedrine(CAS DataBase Reference)
• NIST Chemistry Reference: O,N-diacetylnorephedrine(93860-66-3)
• EPA Substance Registry System: O,N-diacetylnorephedrine(93860-66-3)

Safety Data

• Hazardous Substances Data: 93860-66-3(Hazardous Substances Data)

Upstream product

• 126188-49-6 (1S,2S)-N-<(2-Hydroxy-2-phenyl)-1-methyl-ethyl>-acetamid 
• 108-24-7 acetic anhydride 
• 54680-46-5 norephedrine 
• 19220-93-0 pentafluorophenyl acetate 
• 14838-15-4 u-2-amino-1-phenylpropan-1-ol 
• 37577-28-9 (1S,2R)-(+)-norphedrine 
• 154-41-6 norephedrine hydrochloride 

Downstream Products

• 37577-07-4 Norpseudoephedrine 
• 156-34-3 l-amphetamine 
• 14383-60-9 (R)-(-)-N-acetyl-α-methylphenylethylamine 
• 126188-15-6 N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]acetamide 
• 117465-77-7 (1RS:2RS)-2-amino-1-(4-nitro-phenyl)-propanol-⁽¹⁾ 

Relevant articles and documents

Chiral DNA gyrase inhibitors. 3. Probing the chiral preference of the active site of DNA gyrase. Synthesis of 10-fluoro-6-methyl-6,7-dihydro-9- piperazinyl-2H-benzo[a]quinolizin-20-one-3-carboxylic acid analogues

In pursuit of an apparent literature anomaly, S- and R-6-methyl-6,7- dihydro-2H-benzo[a]-quinolizin-2-one-3-carboxylic acids (12 and 22) were synthesized by an unambiguous route from optically active norephedrines, and their antibacterial potencies were measured. Against Gram-negative microorganisms and DNA gyrase a preference for S-absolute configuration was found whereas R-absolute stereochemistry was more active against Gram-positives. These results are in partial conflict with an earlier report. In an attempt to enhance potency, racemic 10-fluoro-9-piperazinyl (35) and related analogues were synthesized by a novel route. The latter analogues were surprisingly unimproved in potency. The implications of these findings are briefly discussed.

Aeruginoguanidines 98-A-98-C: Cytotoxic unusual peptides from the cyanobacterium Microcystis aeruginosa

Aeruginoguanidines 98-A-98-C (1-3) were isolated from the cyanobacterium Microcystis aeruginosa (NIES-98). The structures of aeruginoguanidines 98-A-98-C (1-3) were determined by two-dimensional 1H-1H and 1H-13C NMR correlation experiments and confirmed by mass spectral analysis. The absolute stereochemistry of 1, consisting of Hphpa trisulfate (1-(4-hydroxy-3-hydroxymethyl)phenyl-1-hydroxy-2-propylamine 4′,3′,1-tri-O-sulfate), MpArg (Nα-methyl-Nω-prenylarginine) and MgArg ((Z)-Nα-methyl-Nω-geranylarginine), was determined by the NMR analyses of phenylglycine methyl ester (PGME) or Boc phenylglycine (BPG) derivatives of acid hydrolysates. These compounds showed moderate cytotoxicity against the P388 murine leukemia cells.