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Usage

Uses

Used in Pharmaceutical Industry:
5-Methoxy-2,3-dihydro-benzofuran-2-carboxylic acid is used as a research chemical for the development of new medications targeting neurological and psychiatric disorders. Its interaction with the central nervous system makes it a candidate for potential therapeutic applications, despite the need for careful regulation to prevent abuse.
Used in Traditional Medicine:
In traditional medicine, 5-Methoxy-2,3-dihydro-benzofuran-2-carboxylic acid is used as a natural sedative and calming agent to alleviate symptoms of anxiety and stress. Its historical use is based on the belief in its ability to promote relaxation and mental tranquility.
Used in Neuroscientific Research:
5-Methoxy-2,3-dihydro-benzofuran-2-carboxylic acid serves as a valuable tool in neuroscientific research, particularly in studies exploring the effects of psychoactive substances on perception, mood, and consciousness. Understanding its mechanisms of action can contribute to the advancement of treatments for various neurological conditions.

Upstream product

• 10242-08-7 5-methoxybenzofuran-2-carboxylic acid 
• 50551-56-9 ethyl 5-methoxybenzofuran-2-carboxylate 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 

Downstream Products

• 208842-08-4 (S)-toluenesulfonic acid 5-methoxy-2,3-dihydro-benzofuran-2-ylmethyl ester 

Relevant academic research and scientific papers

4-hydroxy-piperidine derivatives

The present invention relates to 4-hydroxy-piperidine derivatives of the general formula wherein X denotes —O—, —NH—, —CH2—, —CH═, —CHOH—, —CO—, —S—, —SO— or —SO2—; R1-R4are, independently from each other, hydrogen, hydroxy, lower-alkyl-sulfonylamino, 1- or 2-imidazolyl or acetamido; R5-R8are, independently from each other, hydrogen, hydroxy, lower-alkyl, halogen, lower-alkoxy, trifluoromethyl or trifluoromethyloxy; a and b may be a double bond, provided that when “a” is a double bond, “b” cannot be a double bond; n is 0-2; m is 1-3; p is 0 or 1 and to pharmaceutically acceptable addition salts thereof. Compounds of the present invention are NMDA(N-methyl-D-aspartate)-receptor subtype selective blockers, which can be used in mediating processes underlying development of CNS including learning and memory formation and function.

α-Adrenoreceptor Reagents. 2. Effects of Modification of the 1,4-Benzodioxan Ring System on α-Adrenoreceptor Activity

Modification of the 1,4-benzodioxan ring present in RX 781094 (1) has not previously been considered.This paper describes a number of analogues of this ring system, including compounds in which one of the oxygen atoms has been replaced by a methylene group and also those in which the ring size has been changed to give, for example, furan and thiophene derivatives.The dihydroxybenzofuranylimidazoline compound 7 is the only analogue possesing presynaptic antagonist potency and selectivity comparable to that of 1.In view of this result, a number of derivatives was prepared to determine the structure-activity relationships within this series.Many derivatives, as well as the parent compound 7, were found to possess presynaptic α2-adrenoreceptor antagonist and postsynaptic α1-adrenoreceptor partial agonist properties.Two of the selective presynaptic antagonists,13 and 14, possess greater potency and selectivity than that possessed by 1.The 5-chloro derivative 25 is twice as potent as 1 after oral administration but only about half as potent when given intravenously.