939039-44-8Relevant articles and documents
Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors
Wang, Yufeng,Yang, Wu,Finlay, Heather J.,Harikrishnan, Lalgudi S.,Jiang, Ji,Kamau, Muthoni G.,Van Kirk, Katy,Nirschl, David S.,Taylor, David S.,Chen, Alice Ye A.,Yin, Xiaohong,Sleph, Paul G.,Yang, Richard Z.,Huang, Christine S.,Adam, Leonard P.,Lawrence, R. Michael,Wexler, Ruth R.,Salvati, Mark E.
, p. 860 - 864 (2014/02/14)
A series of diphenylpyridylethanamine-based inhibitors of cholesteryl ester transfer protein with aminoheterocycles appended onto the N-terminus of the chemotype were explored as urea mimetics. Potent compounds were discovered and were further optimized to improve metabolic stability and PXR transactivation profile.
