93933-49-4

Usage

Uses

Used in Organic Synthesis:
2-Amino-4-bromobenzenethiol is used as a building block in organic synthesis for its reactivity and structural properties, enabling the creation of a wide range of organic compounds.
Used in Pharmaceutical Research:
In pharmaceutical research, 2-Amino-4-bromobenzenethiol is utilized as a key component in the development of new drugs, owing to its potential to contribute to the synthesis of therapeutically relevant molecules.
Used in Dye and Pigment Production:
2-AMINO-4-BROMOBENZENETHIOL is also used in the production of dyes and pigments, where its chemical structure contributes to the color and stability of these products.
Used in Therapeutic Agent Development:
2-Amino-4-bromobenzenethiol has been studied for its potential pharmacological properties, and it is considered as a candidate for the development of therapeutic agents for the treatment of various diseases and disorders, highlighting its multifaceted utility in the medical field.

Upstream product

• 20358-03-6 5‐bromo‐1,3‐benzothiazol‐2‐amine 
• 63837-11-6 5-bromo-2-methylbenzothiazole 
• 3460-18-2 1,4-dibromo-2-nitrobenzene 
• 76209-02-4 4-bromo-2-nitrobenzenethiol 
• 76209-05-7 4,4′-dibromo-2,2′-dinitrodiphenyl disulfide 

Downstream Products

• 95081-28-0 6-bromo-2-(p-chlorobenzoyl)-3-methyl-4H-1,4-benzothiazine 
• 199475-45-1 5-bromo-1,3-benzothiazol-2(3H)-one 
• 7038-31-5 2-amino-4-bromo-benzenethiol dimer 
• 768-11-6 5-bromo-benzthiazole 
• 1421278-68-3 N-(4-bromo-2-((3-nitropyridin-2-yl)thio)phenyl)acetamide 
• 305790-48-1 6-bromo-1-methyl-1,3-dihydro-2H-benzo[d]imidazole-2-one 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of benz-fused five-membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities

A series of benz-fused five-membered heterocyclic compounds were designed and synthesized as novel tubulin inhibitors targeting the colchicine binding site. Among them, compound 4d displayed the highest antiproliferative activity against four cancer cell lines with an IC50 value of 4.9?μM in B16-F10 cells. Compound 4d effectively inhibited tubulin polymerization in vitro (IC50 of 13.1?μM). Further, 4d induced cell cycle arrest in G2/M phase. Finally, 4d inhibited the migration of cancer cells in a dose-dependent manner. In summary, these results suggest that compound 4d represents a new class of tubulin inhibitors deserving further investigation.

Catalytic enantioselective one-pot approach to cis- and trans-2,3-diaryl substituted 1,5-benzothiazepines

The first enantioselective catalytic approach to cis- and trans-2,3-diaryl substituted 1,5-benzothiazepines has been conveniently developed in a one-pot fashion, starting from α,β-unsaturated acyl pyrazoles and 2-aminothiophenol. The organocatalytic two-s

Catalytic Enantioselective Synthesis of Protecting-Group-Free 1,5-Benzothiazepines

A one-pot enantioselective route to N-unprotected 2,3-dihydro-1,5-benzothiazepinones, by an organocatalyzed sulfa-Michael reaction of readily available α,β-unsaturated N-acyl pyrazoles with 2-aminothiophenols followed by silica-gel-catalyzed lactamization

Indoline dyes with benzothiazole unit for dye-sensitized solar cells

We report a new series of indoline dyes with a donoraromatic-acceptor (D-π-A) structure. D-π-A metal-free organic dyes with indoline-benzothiazole-rhodanine units were synthesized and their photovoltaic performances were evaluated. The photoelectric conversion efficiency (η) of the indoline-benzothiazole-rhodanine dye is 3.7%, while that of the indolinethiophene-rhodanine dye is 0.9% under the same conditions. The incident photon-to-current conversion efficiencies (IPCEs) of these dyes are 60% and 25%, respectively, at 500 nm. To understand their electronic structures, the geometries of the dyes were optimized by density functional theory (DFT) calculations at the 6-31G(d) level using a B3LYP exchange-correlation functional. As a result, the localized highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) of the indoline?benzothiazole?rhodanine dye were obtained and were compared with those of the indoline-thiophene-rhodanine dye.

COMPOUNDS FOR THE MODULATION OF MYC ACTIVITY

The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angio genesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.

INHIBITORS OF HIF PROLYL HYDROXYLASE

The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.

Facile net cycloaddition approach to optically active 1,5-benzothiazepines

The 1,5-benzothiazepine moiety is well-known as a versatile pharmacophore, and its derivatives are expected to have antagonism against numerous diseases. Thus, it is desirable to develop a synthetic route that enables facile enantioselective preparation of a wide range of such derivatives. Although the cycloaddition approach could be considered a possible route to these compounds, to date, there has been no precedent of such a protocol. We therefore present the first example of a highly enantioselective net [4 + 3] cycloaddition to afford 1,5-benzothiazepines by utilizing α,β-unsaturated acylammonium intermediates generated by chiral isothiourea catalysts, which undergo two sequential chemoselective nucleophilic attacks by 2-aminothiophenols. This protocol provided cycloadducts in extremely high regioselectivity, with a good-to-excellent stereoselectivity being achieved regardless of the steric and electronic properties of the substrates. This method therefore offers promising synthetic routes for the construction of a library of optically active 1,5-benzothiazepines for assay evaluation.

COMPOUNDS FOR TREATMENT OF DRUG RESISTANT AND PERSISTENT TUBERCULOSIS

Described herein are compounds and compositions for treating drug resistant and persistent tuberculosis. Also described herein is a method of screening for identifiying biofilm formation inhibitors.

Fused bicyclic-substituted amines as histamine-3 receptor ligands

Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions.

Fused bicyclic-substituted amines as histamine-3 receptor ligands

Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions.