939376-95-1

Basic information

• Product Name: 5-bromo-2-phenyl-oxazole-4-carboxylic acid
• CAS NO: 939376-95-1
• Molecular Weight: 268.067
• Mol File: 939376-95-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-bromo-2-phenyl-oxazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-phenyl-oxazole-4-carboxylic acid(939376-95-1)
• EPA Substance Registry System: 5-bromo-2-phenyl-oxazole-4-carboxylic acid(939376-95-1)

Safety Data

• Hazardous Substances Data: 939376-95-1(Hazardous Substances Data)

Upstream product

• 98-80-6 phenylboronic acid 
• 460081-28-1 5-bromo-2-phenyl-oxazole-4-carboxylic acid ethyl ester 
• 39819-39-1 2-phenyl-oxazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors

In a discovery effort to find safe and effective DGAT-1 inhibitors, we have identified 2-phenyloxazole 4-carboxamide 1 as a conformationally constrained analog of a hydrazide hit, which was previously identified from high-throughput screening. Further optimization of this series has led to chemically more stable 2-phenyloxazole-based DGAT-1 inhibitor 25 with improved solubility, cell-based activity, and pharmacokinetic properties. Compound 25 also demonstrated in vivo efficacy in a diet-induced obesity (DIO) rat model.