939399-79-8Relevant academic research and scientific papers
Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity
Negmeldin, Ahmed T.,Padige, Geetha,Bieliauskas, Anton V.,Pflum, Mary Kay H.
supporting information, p. 281 - 286 (2017/03/17)
Histone deacetylase (HDAC) proteins are epigenetic regulators that deacetylate protein substrates, leading to subsequent changes in cell function. HDAC proteins are implicated in cancers, and several HDAC inhibitors have been approved by the FDA as antica
Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid
Bieliauskas, Anton V.,Weerasinghe, Sujith V.W.,Pflum, Mary Kay H.
, p. 2216 - 2219 (2007/10/03)
Inhibitors of histone deacetylase (HDAC) proteins such as suberoylanilide hydroxamic acid (SAHA) have emerged as effective therapeutic anti-cancer agents. To better understand the structural requirements of HDAC inhibitors, a small molecule library with a
