93953-18-5Relevant academic research and scientific papers
Reactions of Alkylidenecarbenes Derived from N,N-Disubstituted-2-oxopropanamides: The Formation of 3-Pyrrol-2-ones and 2-Butynamides
Gilbert, John C.,Blackburn, Brent K.
, p. 3656 - 3663 (1986)
Activation of C-H bonds toward insertion by an alkylidenecarbene was examined in the reaction of N,N-disubstituted-2-oxopropanamides with diethyl (diazomethyl)phosphonate under basic reaction conditions.The intermediate alkylidenecarbene expected to be fo
3-PYRROL-2-ONES FROM PYRUVAMIDES: MECHANISTIC AND SYNTHETIC ASPECTS
Gilbert, John C.,Blackburn, Brent K.
, p. 4067 - 4070 (2007/10/02)
3-Pyrrol-2-ones, 4, and 2-butynamides, 5, are formed by reaction of N,N-dialkylated pyruvamides, 2, with diethyl (diazomethyl)phosphonate (1).The selectivity of the C-H insertion reaction to give 4 and the basis for it are discussed.
