93953-36-7Relevant academic research and scientific papers
A concise and versatile synthesis of 2-amino-3-cyanopyridine derivatives in 2,2,2-trifluoroethanol
Khaksar, Samad,Yaghoobi, Mandana
, p. 41 - 44 (2012/11/06)
Trifluoroethanol (TFE) is found to be an efficient and recyclable medium in promoting one-pot, four-component coupling reactions of aldehydes, ketones, malononitrile, and ammonium acetate to afford the corresponding 2-amino-3-cyanopyridine derivatives in high yields. The solvent (TFE) can be readily separated from reaction products and recovered in excellent purity for direct reuse.
SnO2/SiO2 nanocomposite catalyzed one-pot, four-component synthesis of 2-amino-3-cyanopyridines
Yelwande, Ajeet A.,Navgire, Madhukar E.,Tayde, Deepak T.,Arbad, Balasaheb R.,Lande, MacHhindra K.
experimental part, p. 131 - 137 (2012/09/05)
An efficient and rapid protocol for the synthesis of 2-amino-3- cyanopyridines by the cyclocondensation reaction of aromatic aldehydes, methyl ketones, malononitrile and ammonium acetate catalyzed by SnO2/ SiO2 nanocomposite material
One-pot synthesis of 2-amino-3-cyanopyridine derivatives catalyzed by ytterbium perfluorooctanoate [Yb(PFO)3]
Tang, Jun,Wang, Limin,Yao, Yinfang,Zhang, Liang,Wang, Wenbo
supporting information; experimental part, p. 509 - 511 (2011/03/18)
A family of 2-amino-3-cyanopyridine derivatives are synthesized from aldehydes, ketones, malononitrile, and ammonium acetate via one-pot reaction catalyzed by ytterbium perfluorooctanoate [Yb(PFO)3]. This procedure tolerates most of substrates
Ring Transformation Reactions of 1-Substituted 2(1H)-Pyrimidinones and Related Compounds with Active Methylene Compounds
Katoh, Akira,Omote, Yoshimori,Kashima, Choji
, p. 2942 - 2946 (2007/10/02)
1-Substituted 2(1H)-pyrimidinones (I) underwent ring transformation with malononitrile and ethyl acetoacetate in the presence of sodium ethoxide to give 2-amino-3-pyridinecarbonitriles (II-VII) and N-(substituted)amino-3-pyridinecarboxylic acids (XIV and XV), respectively.Further, I reacted with ethyl cyanoacetate, dialkyl malonate, or ethyl benzoylacetate to give pyridine derivatives (VIII-XIII) bearing various functional groups at the C-3 position.The reaction of 1-substituted 2(1H)-pyrimidinethiones and 4,6-dimethyl-1-phenyl-2-phenylimino-1,2-dihydropyrimidine with active methylene compounds is also discussed.Keywords - ring transformation; 1-substituted 2(1H)-pyrimidinone; 1-substituted 2(1H)-pyrimidinethione; active methylene compound; sodium alkoxide; pyridine derivative.
