93969-90-5Relevant academic research and scientific papers
Toward an optimal joint recognition of the s1′ subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP)
Inguimbert, Nicolas,Coric, Pascale,Poras, Hervé,Meudal, Hervé,Teffot, Franck,Fournié-Zaluski, Marie-Claude,Roques, Bernard P.
, p. 1477 - 1486 (2007/10/03)
The formation of vasoconstrictors (e.g., angiotensin II and endothelin) and the inactivation of vasodilators (e.g., bradykinin and atrial natriuretic) by membrane-bound zinc metallopeptidases are key mechanisms in the control of blood pressure and fluid h
New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: Rational design, bioavailability, and pharmacological responses in experimental hypertension
Fournie-Zaluski,Coric,Turcaud,Rousselet,Gonzalez,Barbe,Pham,Jullian,Michel,Roques
, p. 1070 - 1083 (2007/10/02)
In the treatment of cardiovascular diseases, it could be of therapeutic interest to associate the hypotensive effects resulting from the inhibition of angiotensin II formation, ensured by endothelial angiotensin-converting enzyme (ACE), with the diuretic
A NOVEL ROUTE TO SUBSTITUTED PHOSPHONATES VIA CONJUGATE ADDITION OF ORGANOMETALLICS TO 1-(FUNCTIONALLY) SUBSTITUTED ALKENE PHOSPHONATES.
Barbot, F.,Paraiso, E.,Miginac, Ph.
, p. 4369 - 4370 (2007/10/02)
Organometallics readily add to the double bond of 1-(functionally) substituted alkene phosphonates to give highly substituted phosphonates.
