93971-10-9Relevant academic research and scientific papers
Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling
Hansen, Eric C.,Li, Changfeng,Yang, Sihang,Pedro, Dylan,Weix, Daniel J.
, p. 7085 - 7092 (2017/07/26)
Despite their importance, the synthesis of alkylated heterocycles from the cross-coupling of Lewis basic nitrogen heteroaryl halides with alkyl halides remains a challenge. We report here a general solution to this challenge enabled by a new collection of ligands based around 2-pyridyl-N-cyanocarboxamidine and 2-pyridylcarboxamidine cores. Both primary and secondary alkyl halides can be coupled with 2-, 3-, and 4-pyridyl halides as well as other more complex heterocycles in generally good yields (41 examples, 69% ave yield).
REACTION OF DIALKYLPYRIDINES WITH STYRENE AND MASS-SPECTROMETRIC BEHAVIOR OF THE REACTION PRODUCTS
Tokmurzin, K.Kh.,Turgarina, R.,Zhumagaliev, S.Zh.
, p. 1133 - 1135 (2007/10/02)
The reaction of 2,4-dimethylpyridine with styrene gives 2-(3'-phenyl-propyl)-4-methyl- and 2-methyl-4-(3'-phenylpropyl)pyridine, but in the case of 2-methyl-5-ethylpyridine, the reaction gives only 2-(3'-phenylpropyl)-5-ethylpyridine.The mass spectra of the compounds obtained have been studied.
