93972-06-6

Upstream product

• 52709-83-8 4'-n-butyl-4-cyanobiphenyl 
• 92-52-4 biphenyl 
• 37909-95-8 4-butylbiphenyl 
• 93972-13-5 4'-Butyl-biphenyl-4-carbaldehyde oxime 
• 5720-05-8 4-methylphenylboronic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 145240-28-4 4-butylphenylboronic acid 
• 41492-05-1 p-bromobutylbenzene 
• 87199-17-5 4-formylphenylboronic acid, 
• 13211-01-3 1-([1,1'-biphenyl]-4-yl)butan-1-one 

Downstream Products

• 1451207-36-5 C₃₈H₄₂N₂O₄ 
• 1451207-37-6 C₄₃H₅₀N₂O₆ 
• 1451207-42-3 C₄₂H₄₈N₂O₆ 

Relevant academic research and scientific papers

Gold Catalysts Can Generate Nitrone Intermediates from a Nitrosoarene/Alkene Mixture, Enabling Two Distinct Catalytic Reactions: A Nitroso-Activated Cycloheptatriene/Benzylidene Rearrangement

Gold-catalyzed reactions of cycloheptatrienes with nitrosoarenes yield nitrone derivatives efficiently. This reaction sequence enables us to develop gold-catalyzed aerobic oxidations of cycloheptatrienes to afford benzaldehyde derivatives using CuCl and nitrosoarenes as co-catalysts (10-30 mol %). Our density functional theory calculations support a novel nitroso-activated rearrangement, tropylium → benzylidene. With the same nitrosoarenes, we developed their gold-catalyzed [2 + 2 + 1]-annulations between nitrosobenzene and two enol ethers to yield 5-alkoxyisoxazolidines using 1,4-cyclohexadienes as hydrogen donors.

LINEAR PEPTIDE ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

ANTI-BACTERIAL COMPOSITIONS AND METHODS INCLUDING TARGETING VIRULENCE FACTORS OF STAPHYLOCOCCUS AUREUS

This disclosure relates to compositions and methods including for the inhibition, prevention, and/or treatment of microbial infections, including infections from such pathogens as Staphylococcus aureus.

Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in staphylococcus aureus

Staphylococcus aureus produces a golden carotenoid virulence factor called staphyloxanthin (STX), and we report here the inhibition of the enzyme, dehydrosqualene synthase (CrtM), responsible for the first committed step in STX biosynthesis. The most acti

SYSTEM FOR CONTROLLING THE REACTIVITY OF BORONIC ACIDS

A protected organoboronic acid includes a boron having an sp3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic group bonded to the boron through a boron-carbon bond. A method of performing a chemical reaction includes contacting a protected organoboronic acid with a reagent, the protected organoboronic acid including a boron having an sp3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic group bonded to the boron through a boron-carbon bond. The organic group is chemically transformed, and the boron is not chemically transformed.

SYNTHESIS OF 4-ALKYL-4'-CYANOBIPHENYLS

Liquid crystals of the 4-alkyl-4'-cyanobiphenyl group were synthesized without the use of copper cyanide. 4-Alkyl-4'-formylbiphenyls and the 4-formyloximes of 4'-alkylbiphenyl, which possess a liquid-crystalline state, were isolated.Beginning with the pentyl homolog, they form an enantiotropic nematic phase, and beginning with octyl homolog they also form a smectic meso phase.