939758-80-2

Usage

Structure

Tetrahydroisoquinoline derivative with an iodo substituent at the 5-position of the isoquinoline ring

Applications

a. Organic synthesis
b. Medicinal chemistry
c. Building block for the synthesis of biologically active compounds
d. Development of potential pharmaceuticals

Reactivity

a. Useful reagent in chemical reactions
b. Suzuki coupling
c. Halogenation reactions

Importance

Important intermediate in the preparation of various organic molecules with potential pharmacological applications

Upstream product

• 1125-60-6 isoquinolin-5-ylamine 
• 58142-99-7 5-iodoisoquinoline 

Downstream Products

• 1394241-50-9 C₁₆H₁₄INO₄S 

Relevant academic research and scientific papers

ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to aryl linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhbiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.

ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to aryl linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhbiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.