939986-65-9

Usage

Uses

Used in Pharmaceutical Industry:
6-chloropyrimidine-4-carbonitrile is used as a key intermediate for the synthesis of various biologically active compounds. Its unique structure and reactivity enable the development of novel pharmaceuticals with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 6-chloropyrimidine-4-carbonitrile is utilized as a building block in the production of various agrochemicals. Its incorporation into these products helps enhance their effectiveness in protecting crops and managing pests.
Used in Fine Chemicals Synthesis:
6-chloropyrimidine-4-carbonitrile is employed as a versatile building block in the synthesis of fine chemicals. Its unique properties allow for the creation of high-value products used in various industries, including pharmaceuticals, agrochemicals, and specialty chemicals.
Used in Chemical Process Development:
The reactivity of 6-chloropyrimidine-4-carbonitrile is harnessed in the development of different chemical processes, enabling the production of valuable products with improved properties and performance. This contributes to advancements in both pharmaceutical and agricultural applications, ultimately benefiting human health and food security.

Upstream product

• 121-69-7 N,N-dimethyl-aniline 
• 223788-14-5 ethyl 6-oxo-3,6-dihydropyrimidine-4-carboxylate 
• 98024-63-6 6-hydroxy-4-pyrimidinecarboxamide 
• 1370442-07-1 6-hydroxy-pyrimidine-4-carbaldehyde oxime 

Downstream Products

• 2226735-55-1 (S)-6-(4-(5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbonyl)piperidin-1-yl)pyrimindine-4-carbonitrile 

Relevant academic research and scientific papers

(3-phenylisoxazolidin-2-yl)(piperidin-4-yl)methanone derivatives and pharmaceutical composition for use in preventing or treating kinase-related disease

The present invention relates to a (3-phenylisoxazolidin-2-yl)(piperidin-4-yl)methanone derivative represented by the following chemical formula 1, and a pharmaceutical composition for treating kinase-related diseases including the same as an active ingredient. The (3-phenylisoxazolidin-2-yl)(piperidin-4-yl)methanone derivative according to one aspect shows an excellent activity of inhibiting at least one kinase selected from the group consisting of ABL1, ABL2, BRAF, CDK11, CDK8, CDKL2, CIT, CSF1R, DDR1, DDR2, FLT3, KIT, LOK, LTK, MUSK, PAK3, PDGFRA, PDGFRB, RAF1 and RIPK1, and thus can be used for treating kinase-related diseases.

INDOLE AND AZAINDOLE MODULATORS OF THE ALPHA 7 NACHR

This invention relates to modulation of the α7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a pharmaceutically acceptable salt thereof.

Substituted alkylamine derivatives and methods of use

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.