6-chloropyrimidine-4-carbonitrile

Base Information

• Chemical Name: 6-chloropyrimidine-4-carbonitrile
• CAS No.: 939986-65-9
• Molecular Formula: C5H2ClN3
• Molecular Weight: 139.544
• Hs Code.: 2933599090
• Mol file: 939986-65-9.mol

Synonyms:4-CHLORO-6-CYANOPYRIMIDINE;6-CHLORO-4-PYRIMIDINECARBONITRILE;6-cyano-4-chloropyrimidine;6-chloro-pyrimidine-4-carbonitrile;4-CHLOROPYRIMIDINE-6-CARBONITRILE;

Chemical Property of 6-chloropyrimidine-4-carbonitrile

Chemical Property:

• PSA: 49.57000
• LogP: 1.00168
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-chloropyrimidine-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloropyrimidine-4-carbonitrile

There total 6 articles about 6-chloropyrimidine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-hydroxy-pyrimidine-4-carbaldehyde oxime (1370442-07-1) → 6-chloropyrimindine-4-carbonitrile (939986-65-9)

Guidance literature:

6-hydroxy-pyrimidine-4-carbaldehyde oxime; With trichlorophosphate; at 40 - 80 ℃; for 2h;

With N,N-dimethyl-aniline; at 80 ℃; for 1h;

Reference yield:

6-hydroxy-4-pyrimidinecarboxamide (98024-63-6) → 6-chloropyrimindine-4-carbonitrile (939986-65-9)

Guidance literature:

6-hydroxy-4-pyrimidinecarboxamide; With trichlorophosphate; for 18h; Reflux;

With ammonia; In water; Cooling with ice;

Reference yield:

6-oxo-3,6-dihydropyrimidine-4-carboxamide → 6-chloropyrimindine-4-carbonitrile (939986-65-9)

Guidance literature:

With trichlorophosphate; for 18h; Reflux;

upstream raw materials:

N,N-dimethyl-aniline

6-hydroxy-pyrimidine-4-carbaldehyde oxime

6-hydroxy-4-pyrimidinecarboxamide

ethyl 6-oxo-3,6-dihydropyrimidine-4-carboxylate

Downstream raw materials:

(S)-6-(4-(5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbonyl)piperidin-1-yl)pyrimindine-4-carbonitrile