939987-65-2

Upstream product

• 1363189-01-8 2-{2'-(2''-chloro-4''-fluorophenyl)-2'-oxoethyl}benzoic acid 
• 2252-51-9 2-choro-4-fluorobenzoic acid 
• 89-51-0 Homophthalic acid 
• 21900-54-9 2-chloro-4-fluorobenzoyl chloride 

Downstream Products

• 1094019-58-5 3-(2-chloro-4-fluorophenyl)isoquinolin-1(2H)-one 
• 1036487-52-1 3-(2-chloro-4-fluorophenyl)-1H-isochromene-1-thione 
• 1363189-01-8 2-{2'-(2''-chloro-4''-fluorophenyl)-2'-oxoethyl}benzoic acid 
• 1363189-41-6 (dl)-3-(2'-chloro-4'-fluorophenyl)-3,4-dihydroisocoumarin 
• 1363189-20-1 C₁₅H₁₂ClFO₃ 

Relevant academic research and scientific papers

Synthesis and anti-cancer, anti-metastatic evaluation of some new fluorinated isocoumarins and 3,4-dihydroisocoumarins

Synthesis of some fluorinated isocoumarins and 3,4-dihydroisocoumarins is reported. Structures of the synthesized compounds were confirmed by spectral and elemental analysis. All the synthesized compounds were evaluated for their antimetastatic activity and anti-cancer activity against breast cell line (MCF-7). Among all the tested compounds 3h [3-(3′,4′-difluorophenyl) isocoumarin] has shown excellent antimetastatic activity, however the growth inhibitory response of the tested compounds [3a-h, 4a-h, 5e-h, 6a-h and 7a, c, d] for MCF-7 human breast carcinoma cell line was moderate at higher concentrations (100-400 μM) and negligible at lower concentrations.