940000-26-0

Basic information

• Product Name: (R)-1-N-BOC-2-CYANO-PIPERIDINE
• Synonyms: (R)-2-CYANO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-1-N-BOC-2-CYANO-PIPERIDINE;(R)-TERT-BUTYL 2-CYANOPIPERIDINE-1-CARBOXYLATE;1-N-BOC-2-(R)-CYANO-PIPERIDINE;(R)-1-Boc-2-cyanopiperidine;(R)-N-Boc-2-cyanopiperidine;tert-butyl (2R)-2-cyanopiperidine-1-carboxylate;(2R)-2-Cyano-1-piperidinecarboxylic acid tert-butyl ester
• CAS NO: 940000-26-0
• Molecular Formula: C11H18N2O2
• Molecular Weight: 210.27
• Mol File: 940000-26-0.mol

Chemical Properties

• Boiling Point: 325.3 °C at 760 mmHg
• Flash Point: 150.5 °C
• Appearance: /
• Density: 1.07
• Vapor Pressure: 0.000232mmHg at 25°C
• Refractive Index: 1.487
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-1-N-BOC-2-CYANO-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-N-BOC-2-CYANO-PIPERIDINE(940000-26-0)
• EPA Substance Registry System: (R)-1-N-BOC-2-CYANO-PIPERIDINE(940000-26-0)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3439
• Hazardous Substances Data: 940000-26-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(R)-1-N-BOC-2-CYANO-PIPERIDINE is used as a key intermediate for the production of various drugs, particularly in the development of antiviral and antibacterial agents. Its unique structure allows for the creation of biologically active molecules that can target specific pathogens and diseases.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-1-N-BOC-2-CYANO-PIPERIDINE is utilized as a versatile building block for constructing complex organic molecules. Its BOC protecting group and cyano substituent enable chemists to carry out a range of reactions, facilitating the synthesis of diverse organic compounds with potential applications in various industries.
Used in Medicinal Chemistry Research:
(R)-1-N-BOC-2-CYANO-PIPERIDINE is employed as a valuable research tool in medicinal chemistry. Its reactivity and structural features make it suitable for exploring new drug candidates and understanding the structure-activity relationships of biologically active molecules. (R)-1-N-BOC-2-CYANO-PIPERIDINE contributes to the advancement of drug discovery and development processes.

InChI:InChI=1/C11H18N2O2/c1-11(2,3)15-10(14)13-7-5-4-6-9(13)8-12/h9H,4-7H2,1-3H3/t9-/m1/s1

Upstream product

• 28697-17-8 N-BOC-D-pipecolic acid 
• 848488-91-5 tert-butyl (R)-2-carbamoylpiperidine-1-carboxyl-ate 

Relevant articles and documents

POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY

The present invention is to provide a novel compound (I), having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. Compound (I) wherein Z1 is NR4; R1 is hydrogen or lower alkyl; X is a single bond, a hetero atom group selected from O, S, SO, SO2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene; R2 is optionally substituted aryl; R3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc; and R4 and Z2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound.