940286-56-6Relevant academic research and scientific papers
Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria
Hanessian, Stephen,Pachamuthu, Kandasamy,Szychowski, Janek,Gigure, Alexandre,Swayze, Eric E.,Migawa, Michael T.,Fran?ois, Boris,Kondo, Jiro,Westhof, Eric
, p. 7097 - 7101 (2010)
Incorporation of an hydrophobic (phenethylamino)ethyl ether at C2″ of N1-(HABA)-3′,4′-dideoxyparomomycin led to a novel analog with an excellent antibacterial profile against a host of resistant bacteria.
ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS
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Page/Page column 113, (2010/11/27)
The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
