94038-25-2

Upstream product

• 2759-28-6 1-phenylmethylpiperazine 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 80518-57-6 ethyl 4-(piperazin-1-yl)benzoate 
• 100-52-7 benzaldehyde 

Downstream Products

• 325796-34-7 [4-(4-Benzyl-piperazin-1-yl)-phenyl]-methanol 
• 1092480-71-1 C₃₂H₃₂Cl₂N₈O 
• 1092480-18-6 C₂₉H₂₇Cl₂N₇O 
• 1092480-25-5 C₂₅H₂₆Cl₂N₆O 
• 1092481-44-1 C₂₂H₂₄N₆ 
• 1092481-67-8 C₂₀H₂₀N₆ 
• 1092481-64-5 C₁₇H₂₂N₆ 

Relevant academic research and scientific papers

Base-Mediated Oxidative Degradation of Secondary Amides Derived from p-Amino Phenol to Primary Amides in Drug Molecules

One of the most common functional groups encountered in drug molecules is the amide, and the most common degradation pathway for amides is base-mediated hydrolysis to its constituent amine and carboxylic acid. Herein, we report for the first time, a base-

PIPERIDINE/PIPERAZINE DERIVATIVES

The invention further relates to a DGAT inhibitor of formula (I), including any stereochemically isomeric form thereof, wherein A represents CH or N; the dotted line represents an optional bond in case A represents a carbon atom; X represents -NRx -C(=O)-; -Z-C(=O)-; -Z-NRx -C(=O)-; -S(=O)p-; C(=S)-; -NRx -C(=S)-; -Z-C(=S)-; -Z-NRx -C(=S)-; -O-C(=O)-; -C(=O)-C(=O)-; R1 represents a 5-membered monocyclic heterocycle containing at least 2 heteroatoms; a 6-membered aromatic monocyclic heterocycle; or a 5-membered heterocycle containing at least 2 heteroatoms fused with phenyl, cyclohexyl or a 5-or 6-membered heterocycle; wherein each of said heterocycles may optionally be substituted; R2 represents R3; R3 represents C3-6cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxolyl, 2,3-dihydrobenzofuranyl or a 6-membered aromatic heterocycle containing 1 or 2 N atoms,wherein said C3-6cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzo- dioxinyl, 1,3-benzodioxolyl,2,3-dihydrobenzofuranyl or 6-membered aromatic heterocycle may optionally be substituted; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds.

Anti-virally active pyridazinamines

Anti-virally active pyridazinamines, compositions containing the same and methods of treating viral diseases in warm-blooded animals.

High pressure organic chemistry; XII. A convenient synthesis of aromatic amines from activated aromatic fluorides

Aromatic fluorides containing electron-withdrawing substituents are cleanly reacted with amines at 10 kbar pressure to give various aromatic amines.