940868-17-7

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, phenylmethyl ester
• Synonyms: 1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, phenylmethyl ester;1-Cbz-2-piperidinecarboxamide;2-Carbamoylpiperidine-1-carboxylic acid benzyl ester;1-Cbz-Pipecolinamide;Benzyl 2-carbaMoylpiperidine-1-carboxylate
• CAS NO: 940868-17-7
• Molecular Formula: C₁₄H₁₈N₂O₃
• Molecular Weight: 262.3
• Mol File: 940868-17-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 475.495 °C at 760 mmHg
• Flash Point: 241.371 °C
• Appearance: /
• Density: 1.224 g/cm³
• Vapor Pressure: 3.3E-09mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, phenylmethyl ester(940868-17-7)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, phenylmethyl ester(940868-17-7)

Safety Data

• Hazardous Substances Data: 940868-17-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

InChI:InChI=1/C14H18N2O3/c15-13(17)12-8-4-5-9-16(12)14(18)19-10-11-6-2-1-3-7-11/h1-3,6-7,12H,4-5,8-10H2,(H2,15,17)

Upstream product

• 28697-07-6 N-benzyloxycarbonyl D/L-pipecolinic acid 
• 501-53-1 benzyl chloroformate 
• 4043-87-2 pipecolic Acid 
• 28697-11-2 (S)-1-(carbobenzyloxy)-2-piperidinecarboxylic acid 
• 543-27-1 isobutyl chloroformate 

Downstream Products

• 519028-71-8 benzyl 2-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)piperidine-1-carboxylate 
• 519028-92-3 N-(4-fluorobenzyl)-5,6-dihydroxy-2-piperidin-2-ylpyrimidine-4-carboxamide 
• 940868-21-3 benzyl 2-[(Z)-amino(hydroxyimino)methyl]piperidine-1-carboxylate 
• 1017788-63-4 2-cyanopiperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors

Human immunodeficiency virus type-1 (HIV-1) integrase, one of the three constitutive viral enzymes required for replication, is a rational target for chemotherapeutic intervention in the treatment of AIDS that has also recently been confirmed in the clinical setting. We report here on the design and synthesis of N-benzyl-5,6-dihydroxypyrimidine-4-carboxamides as a class of agents which exhibits potent inhibition of the HIV-integrase-catalyzed strand transfer process. In the current study, structural modifications on these molecules were made in order to examine effects on HIV-integrase inhibitory potencies. One of the most interesting compounds for this series is 2-[1-(dimethylamino)-1-methylethyl]-N-(4-fluorobenzyl)-5,6-dihydroxypyrimidine- 4-carboxamide 38, with a CIC95 of 78 nM in the cell-based assay in the presence of serum proteins. The compound has favorable pharmacokinetic properties in preclinical species (rats, dogs, and monkeys) and shows no liabilities in several counterscreening assays, highlighting its potential as a clinically useful antiviral agent.

Tripeptides acting on the central nervous system and a process for the preparation thereof

The invention relates to new peptide derivatives which act on the central nervous system and correspond to the general formula (I), wherein X is L-norleucyl, L-leucyl, L-norvalyl, D-leucyl, L-prolyl, L-2-aminobutyryl, L-valyl, L-threonyl, L-isoleu