77017-20-0

Basic information

• Product Name: 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
• Synonyms: 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate;16,17-Dihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate;16-alpha,17-alpha-dihydroxy-3,20-dioxopregna- 1,4,9(11)-trien-21-yl acetate;Pregna-1,4,9(11)-triene-16,17-diol-3,20-dione 21-acetate;21-(Acetyloxy)-16α,17-dihydroxypregna-1,4,9(11)-triene-3,20-dione;(16α)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione
• CAS NO: 77017-20-0
• Molecular Formula: C₂₃H₂₈O₆
• Molecular Weight: 400.46482
• EINECS: 278-593-2
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 77017-20-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 213-215 °C(Solv: acetone (67-64-1); ligroine (8032-32-4))
• Boiling Point: 576.748°C at 760 mmHg
• Flash Point: 198.046°C
• Appearance: /
• Density: 1.312g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.603
• PKA: 11.92±0.70(Predicted)
• Water Solubility: 38.72mg/L at 25℃
• CAS DataBase Reference: 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate(77017-20-0)
• EPA Substance Registry System: 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate(77017-20-0)

Safety Data

• Hazardous Substances Data: 77017-20-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C23H28O6/c1-13(24)29-12-20(27)23(28)19(26)11-18-16-5-4-14-10-15(25)6-8-21(14,2)17(16)7-9-22(18,23)3/h6-8,10,16,18-19,26,28H,4-5,9,11-12H2,1-3H3/t16-,18+,19-,21+,22+,23+/m1/s1

Upstream product

• 37413-91-5 2-((10S,13S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate 
• 37413-91-5 2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate 

Downstream Products

• 51372-29-3 budesonide 
• 76-25-5 triamcinolone acetonide 
• 215095-77-5 C₂₁H₂₆O₆ 
• 13951-70-7 desonide 
• 86401-80-1 11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate 
• 3385-03-3 flunisolide 
• 4533-89-5 21-(acetyloxy)-6α-fluoro-11β-hydroxy-16α,17-<(1-methylethylidene)bis(oxy)>pregna-1,4-diene-3,20-dione 
• 638-94-8 desonide 
• 126544-47-6 ciclesonide 
• 161115-59-9 desisobutyryl ciclesonide 
• 51372-28-2 (22S)-Budesonide 

Relevant articles and documents

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Preparation method of triamcinolone acetonide

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of triamcinolone acetonide. To the method, the epoxy compound I is taken as a raw material, 70% pyridine hydrofluoric acid solution is used as a fluorinated reagent, then the amount of hydrofluoric acid is reduced, reaction conditions are reduced, and reaction steps are optimized.

A budesonide industrial preparation method (by machine translation)

The invention relates to a cloth budesonide industrial preparation method. Specifically, the invention relates to a hydrochloric acid aqueous solution, dichloromethane and in acetonitrile, 16 α - hydroxy prednisolone with butyraldehyde by the reaction of the budesonide. In the method of the present invention has the industrial can be implemented on, repeatability and the like. (by machine translation)