94089-72-2Relevant academic research and scientific papers
Synthesis of (-)-Cytisine Using a 6- endo aza-Michael Addition
Barát, Viktor,Csókás, Dániel,Bates, Roderick W.
supporting information, p. 9088 - 9095 (2018/07/25)
An asymmetric synthesis of (-)-cytisine has been achieved. The piperidine C-ring was formed using a stereodivergent intramolecular 6-endo aza-Michael addition. The B-ring was established by intramolecular pyridine N-alkylation. The absolute stereochemistry was established by an Evans acyl oxazolidinone enolate alkylation reaction that proceeded with an unexpected stereochemical outcome due to participation of the pyridine nitrogen lone pair.
Acyl and Sulfonyl Isocyanates ib β-Lactam Synthesis
Barrett, Anthony G. M.,Betts, Michael J.,Fenwick, Ashley
, p. 169 - 175 (2007/10/02)
The preparation of β-lactams from the reactions of several acyl and sulfonyl activated isocyanates with alkenes was studied.Three compounds, (2,2,2-trichloroethoxy)sulfonyl, 2,2,2-trichloroethane sulfonyl, and trifluoroacetyl isocyanates, were shown to be
