940903-59-3

Basic information

• Product Name: 4-bromo-4,4-difluoro-3-phenylamino-butyric acid ethyl ester
• Synonyms: 4-bromo-4,4-difluoro-3-phenylamino-butyric acid ethyl ester
• CAS NO: 940903-59-3
• Molecular Weight: 322.149
• Mol File: 940903-59-3.mol

Chemical Properties

• CAS DataBase Reference: 4-bromo-4,4-difluoro-3-phenylamino-butyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-4,4-difluoro-3-phenylamino-butyric acid ethyl ester(940903-59-3)
• EPA Substance Registry System: 4-bromo-4,4-difluoro-3-phenylamino-butyric acid ethyl ester(940903-59-3)

Safety Data

• Hazardous Substances Data: 940903-59-3(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 144850-56-6 ethyl 4-bromo-3,3,4,4-tetrafluorobutanoate 

Downstream Products

• 940903-63-9 4-(bromo-difluoro-methyl)-1-phenyl-azetidin-2-one 

Relevant articles and documents

A facile synthesis of 4-gem-difluoromethylene β-lactam and its derivatives from BrCF2CF2Br

4-Bromodifluoromethyl β-lactams 2 are prepared from the commercial available BrCF2CF2Br in overall five-step reaction procedure. Under the radical reaction conditions (Bu3SnH/AIBN), compound 2 reacted with alkenes affording to the corresponding addition product difluoromethylene β-lactams 7. In the absence of alkenes, it can be converted into the corresponding difluoromethyl β-lactam 6 in almost quantitative yield. Furthermore, allylic stannic reagent Bu3SnCH2CH{double bond, long}CH2 reacted with 2 under the same reaction conditions gave the allylic addition product 8.